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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Beta-klotho
Summary
- UniProt ID
- Q86Z14
- Gene Symbol
-
- KLB
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- Q86Z14
- PubChem
- Q86Z14
- The Human Metabolome Database
- HMDBP12679
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Glycoprotein
- Reference proteome
- Repeat
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| GO Term |
|---|
| hydrolase activity, hydrolyzing O-glycosyl compounds |
| fibroblast growth factor binding |
| fibroblast growth factor receptor binding |
Sequence
MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKNLQHIPLKKGKRVVS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 66 |
|
|||
| 71 | N-linked (GlcNAc...) asparagine |
|
||
| 120 | N-linked (GlcNAc...) asparagine |
|
||
| 125 | N-linked (GlcNAc...) asparagine |
|
||
| 211 | N-linked (GlcNAc...) asparagine |
|
||
| 262 |
|
|
||
| 308 | N-linked (GlcNAc...) asparagine |
|
||
| 391 | N-linked (GlcNAc...) asparagine | |||
| 554 | N-linked (GlcNAc...) asparagine |
|
||
| 611 | N-linked (GlcNAc...) asparagine |
|
G83460ZZ
G64409MC
G62765YT
G74724QE
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| FRS-mediated FGFR4 signaling | Homo sapiens |
| Negative regulation of FGFR4 signaling | Homo sapiens |
| PI-3K cascade:FGFR4 | Homo sapiens |
| PI3K Cascade | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
| Phospholipase C-mediated cascade; FGFR4 | Homo sapiens |
| RAF/MAP kinase cascade | Homo sapiens |
| SHC-mediated cascade:FGFR4 | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
