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Fibroblast growth factor receptor substrate 2

Summary

UniProt ID

Q8C180

Gene Symbol

Frs2
Frs2a

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8C180
PubChem: Q8C180
O-GlcNAcAtlas: Q8C180

Annotation

Keyword

Direct protein sequencing
Membrane
Myristate
Phosphoprotein
Reference proteome
Ubl conjugation

Gene Ontology (GO)

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GO Term
lens placode formation involved in camera-type eye formation
neuroblast proliferation
fibroblast growth factor receptor signaling pathway
regulation of apoptotic process
regulation of epithelial cell proliferation
anterior/posterior axis specification, embryo
negative regulation of cardiac muscle cell differentiation
organ induction
lens development in camera-type eye
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying **all 5** entries
GO Term
cytosol
adherens junction
cytoplasm
plasma membrane
cell-cell junction

Displaying **all 3** entries
GO Term
transmembrane receptor protein tyrosine kinase adaptor activity
neurotrophin TRKA receptor binding
fibroblast growth factor receptor binding

Annotation information from UniProt.

Sequence

MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGVMELTDTELILYTRKRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNMLQEIMQNNSINVVEEPVVERSSHQTELEVPRTPRTPTTPGLGAQNLPNGYPRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTTGVQEERKNRASVHVPPEARVSNAESNTPKEEPSNPEDRDPQVLLKPEGVRFVLGPTPVQKQLMEKEKLEQLGKDPVSGSGAGNTEWDTGYDSDERRDVPPVNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRPALLNYENLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTVPASAHKIDYSKRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTRHNSTDLPM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
256				GlyGen
329			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 21 in total

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Pathway Name	Organism
Activated NTRK2 signals through FRS2 and FRS3	Mus musculus
FRS-mediated FGFR1 signaling	Mus musculus
FRS-mediated FGFR2 signaling	Mus musculus
FRS-mediated FGFR3 signaling	Mus musculus
FRS-mediated FGFR4 signaling	Mus musculus
Frs2-mediated activation	Mus musculus
Negative regulation of FGFR1 signaling	Mus musculus
Negative regulation of FGFR2 signaling	Mus musculus
Negative regulation of FGFR3 signaling	Mus musculus
Negative regulation of FGFR4 signaling	Mus musculus