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Histone-lysine N-methyltransferase SETD1B
Summary
- UniProt ID
- Q8CFT2
- Gene Symbol
-
- Kiaa1076
- Set1b
- Setd1b
- Gene ID
- 208043
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Activator
- Alternative splicing
- Chromatin regulator
- Chromosome
- Cytoplasm
- Methyltransferase
- Nucleus
- Phosphoprotein
- RNA-binding
- Reference proteome
- S-adenosyl-L-methionine
- Transcription regulation
- Gene Ontology (GO)
| GO Term |
|---|
| nuclear speck |
| nucleus |
| chromosome |
| cytoplasm |
| Set1C/COMPASS complex |
| GO Term |
|---|
| methylation |
| GO Term |
|---|
| RNA binding |
| histone H3K4 monomethyltransferase activity |
| histone H3K4 trimethyltransferase activity |
Sequence
MENSHPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNVRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAISPIVSETLQLSDALKRLKDGSLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPITPRLGTPFSQDSSYSSRQPTPSYLFSQDPTATFKARRHESKFTDAYNRRHEHHYVHNSAVAGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATTFAHTPPPAQTATASGFKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPGTPPGPPPPDSNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSRPSSTGLEDISPTPLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEVDLDLAGDRTPTSERMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPNVLAPNLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQMLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYIPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDIADAPCELTKRDPKSVGVRRRPGRPLELDSGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEDRESTEEEEEEEEEEAEEEEEEGPRSRISSPSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEEEETESITTSKAPAESSSSSSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEEKETAMAAATVVAMAEESMPPAGGQDFEQDRAEVPLGPRGPMRESLGTEEEVDIEAEDEVPEMQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDMLLSPELPARETEEAQLPSPPEHGPESDLDMEPEPPPMLSLPLQPPLPPPRLLRPPSPPPEPETPEPPKPPVPLEPPPEDHPPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPSPGLSSGGLPRTPGRDFSFTPTFPEPSGPLLLPVCPLPTGRRDERTGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQPRPPPQLPPLLPATLAPCPTPIKRKPGRPRRSPPSMLSLDGPLVRPPPGPALGRDLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQPPPPPPPPPVESTKLPFKELDNQWPSEAIPPGPRRDEVTEEYVDLAKVRGPWRRPPKKRHEDLVAPSASPEPSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKREDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Formation of WDR5-containing histone-modifying complexes | Mus musculus |
| PKMTs methylate histone lysines | Mus musculus |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Mus musculus |
