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Proprotein convertase subtilisin/kexin type 9
Summary
- UniProt ID
- Q8NBP7
- Gene Symbol
-
- NARC1
- PCSK9
- PSEC0052
- Gene ID
- 255738
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0012409
- GlyGen
- Q8NBP7
- PubChem
- Q8NBP7
- The Human Metabolome Database
- HMDBP07935
- Re-Glyco
- Q8NBP7
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Apoptosis
- Autocatalytic cleavage
- Calcium
- Cholesterol metabolism
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Lysosome
- Phosphoprotein
- Reference proteome
- Secreted
- Serine protease
- Signal
- Sulfation
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| PCSK9-LDLR complex |
| extracellular region |
| extracellular space |
| cytoplasm |
| lysosome |
| plasma membrane |
| early endosome |
| late endosome |
| endoplasmic reticulum |
| endoplasmic reticulum lumen |
Sequence
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 533 | N-linked (GlcNAc...) asparagine |
G83460ZZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
| Regulation of IGF Activity by IGFBP | Homo sapiens |
| VLDLR internalisation and degradation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13810 | familial hypercholesterolemia | |
| DOID:1390 | hypobetalipoproteinemia |
