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Integrin beta-3

Summary

UniProt ID

Q8R2H2

Gene Symbol

Itgb3

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q8R2H2

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
positive regulation of cell migration
apoptotic cell clearance
positive regulation of angiogenesis
positive regulation of endothelial cell migration
negative regulation of macrophage derived foam cell differentiation
positive regulation of fibroblast migration
smooth muscle cell migration
positive regulation of smooth muscle cell migration
platelet activation
negative regulation of lipid transport

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GO Term
focal adhesion
integrin complex
external side of plasma membrane
cell surface
ruffle membrane
integrin alphav-beta3 complex
alphav-beta3 integrin-PKCalpha complex
alphav-beta3 integrin-IGF-1-IGF1R complex
alphav-beta3 integrin-HMGB1 complex
alpha9-beta1 integrin-ADAM8 complex

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GO Term
enzyme binding
metal ion binding
vascular endothelial growth factor receptor 2 binding
cell adhesion molecule binding
extracellular matrix binding
fibrinogen binding
C-X3-C chemokine binding
insulin-like growth factor I binding
identical protein binding
fibronectin binding

Annotation information from UniProt.

Sequence

MRTRRPGQLWATLLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDESLPQNSPRCNLKKNLLKDKCSPESIEFPVSEAQILEALPLSSKGSGDSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMFISPPQAIKNPCYTMKSTCLPMFGYKHVLTLTDQVTRFNDEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVLPNDGRCHIGPDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVSLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPQQKEQSFTIKPVGFKDSLTVQVTFDCDCDCQAFAQPLSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCNCGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPDACSFKKDCVECKKFNRGKLHEENNCNRFCRDDIELVKELTDTGKNAVNCTYKNEDDCVVRFQYYEDSSGRAVLYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
345	N-linked (GlcNAc...) asparagine	UniProt
396	N-linked (GlcNAc...) asparagine	UniProt
477	N-linked (GlcNAc...) asparagine	UniProt
584	N-linked (GlcNAc...) asparagine	UniProt
679	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
ECM proteoglycans	Rattus norvegicus
Elastic fibre formation	Rattus norvegicus
GRB2:SOS provides linkage to MAPK signaling for Integrins	Rattus norvegicus
Integrin cell surface interactions	Rattus norvegicus
Integrin signaling	Rattus norvegicus
MAP2K and MAPK activation	Rattus norvegicus
Molecules associated with elastic fibres	Rattus norvegicus
PECAM1 interactions	Rattus norvegicus
Platelet degranulation	Rattus norvegicus
Signal transduction by L1	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements