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Integrin beta-3

Summary

UniProt ID

Q8R2H2

Gene Symbol

Itgb3

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q8R2H2

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
positive regulation of cell migration
apoptotic cell clearance
positive regulation of angiogenesis
positive regulation of endothelial cell migration
negative regulation of macrophage derived foam cell differentiation
positive regulation of fibroblast migration
smooth muscle cell migration
positive regulation of smooth muscle cell migration
platelet activation
negative regulation of lipid transport

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GO Term
filopodium membrane
microvillus membrane
nucleoplasm
focal adhesion
integrin complex
external side of plasma membrane
cell surface
ruffle membrane
integrin alphav-beta3 complex
alphav-beta3 integrin-PKCalpha complex

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GO Term
enzyme binding
metal ion binding
vascular endothelial growth factor receptor 2 binding
cell adhesion molecule binding
extracellular matrix binding
fibrinogen binding
C-X3-C chemokine binding
insulin-like growth factor I binding
identical protein binding
fibronectin binding

Annotation information from UniProt.

Sequence

MRTRRPGQLWATLLALGALAGVVVGESNICTTRGVNSCQQCLAVSPVCAWCSDESLPQNSPRCNLKKNLLKDKCSPESIEFPVSEAQILEALPLSSKGSGDSAQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDDLSSIQTLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMFISPPQAIKNPCYTMKSTCLPMFGYKHVLTLTDQVTRFNDEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVLPNDGRCHIGPDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVSLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPQQKEQSFTIKPVGFKDSLTVQVTFDCDCDCQAFAQPLSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQEECSPKEGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCNCGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCEKCPTCPDACSFKKDCVECKKFNRGKLHEENNCNRFCRDDIELVKELTDTGKNAVNCTYKNEDDCVVRFQYYEDSSGRAVLYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
345	N-linked (GlcNAc...) asparagine	UniProt
396	N-linked (GlcNAc...) asparagine	UniProt
477	N-linked (GlcNAc...) asparagine	UniProt
584	N-linked (GlcNAc...) asparagine	UniProt
679	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Syndecan interactions	Rattus norvegicus
TGF-beta receptor signaling activates SMADs	Rattus norvegicus
VEGFA-VEGFR2 Pathway	Rattus norvegicus
p130Cas linkage to MAPK signaling for integrins	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements