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Cyclin-dependent kinase 8

Summary

UniProt ID

Q8R3L8

Gene Symbol

Cdk8

Gene ID

264064

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q8R3L8
PubChem: Q8R3L8
The O-GlcNAc Database: Q8R3L8
O-GlcNAcAtlas: Q8R3L8
Re-Glyco: Q8R3L8

Annotation

Keyword

ATP-binding
Activator
Alternative splicing
Nucleus
Reference proteome
Repressor
Serine/threonine-protein kinase
Transcription regulation

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
protein-containing complex
nucleoplasm
ubiquitin ligase complex
mediator complex
CKM complex
nucleus
nucleolus

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 3** entries
GO Term
positive regulation of transcription by RNA polymerase II
negative regulation of triglyceride metabolic process
protein ubiquitination

Displaying **all 10** entries
GO Term
cyclin-dependent protein serine/threonine kinase activity
protein kinase activity
ATP binding
ubiquitin protein ligase activity
protein serine kinase activity
RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
RNA polymerase II CTD heptapeptide repeat S2 kinase activity
RNA polymerase II CTD heptapeptide repeat T4 kinase activity
RNA polymerase II CTD heptapeptide repeat S5 kinase activity
RNA polymerase II CTD heptapeptide repeat S7 kinase activity

Annotation information from UniProt.

Sequence

MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKTQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites