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Toll-like receptor 4

Summary

UniProt ID

Q8SPE9

Gene Symbol

TLR4

Organism

Pongo pygmaeus (Bornean orangutan)

External Links

PubChem: Q8SPE9

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
inflammatory response
macrophage activation
innate immune response
positive regulation of interleukin-1 beta production
MyD88-dependent toll-like receptor signaling pathway
defense response to Gram-negative bacterium
detection of lipopolysaccharide
toll-like receptor 4 signaling pathway
positive regulation of NLRP3 inflammasome complex assembly

Displaying **all 4** entries
GO Term
plasma membrane
lipopolysaccharide receptor complex
ruffle
early endosome

Displaying **all 4** entries
GO Term
transmembrane signaling receptor activity
NAD+ nucleotidase, cyclic ADP-ribose generating
lipopolysaccharide binding
lipopolysaccharide immune receptor activity

Annotation information from UniProt.

Sequence

MMSASRLAGTLIPAMAFLSCVRPESWEPCVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQNLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCKDLQVLHQMPLLNLSLDLSLNAMNFIQPGAFKEIRLHKLTLRNSFDSLNVMKTCIQGLAGLEVHHLVLGEFRNEKNLEKFDTSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLANVSSFSLVSVTIKSVKDFSYNFGWQHLELVNCKFGQFPTLELKSLKRLTFTANKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNDVITMGSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLKVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNITCQMNKTVIGVSVFSVLVVSVVAVLVYKFYFHLMLLAGCIKYGRGENTYDAFVIYSSQDEDWVRNELVKNLEEGVPTFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	Source
33	N-linked (GlcNAc...) asparagine	UniProt
171	N-linked (GlcNAc...) asparagine	UniProt
203	N-linked (GlcNAc...) asparagine	UniProt
280	N-linked (GlcNAc...) asparagine	UniProt
307	N-linked (GlcNAc...) asparagine	UniProt
495	N-linked (GlcNAc...) asparagine	UniProt
524	N-linked (GlcNAc...) asparagine	UniProt
573	N-linked (GlcNAc...) asparagine	UniProt
622	N-linked (GlcNAc...) asparagine	UniProt
628	N-linked (GlcNAc...) asparagine	UniProt