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MIRAGE
Connector enhancer of kinase suppressor of ras 2

Summary
UniProt ID
Q8WXI2
Gene Symbol
  • CNK2
  • CNKSR2
  • KIAA0902
  • KSR2
Gene ID
22866
Organism
Homo sapiens (human)
GlyGen
Q8WXI2
PubChem
Q8WXI2
The O-GlcNAc Database
Q8WXI2
Re-Glyco
Q8WXI2
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Coiled coil
  • Cytoplasm
  • Disease variant
  • Intellectual disability
  • Membrane
  • Phosphoprotein
  • Reference proteome
Gene Ontology (GO)
Displaying all 6 entries
GO Term
cytoplasm
plasma membrane
neuronal cell body
extracellular exosome
extrinsic component of postsynaptic density membrane
glutamatergic synapse
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
protein kinase binding
identical protein binding
Annotation information from UniProt.
Sequence
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
332
898
900
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 7 entries
Pathway Name Organism
MAP2K and MAPK activation Homo sapiens
Paradoxical activation of RAF signaling by kinase inactive BRAF Homo sapiens
Signaling by BRAF and RAF1 fusions Homo sapiens
Signaling by RAF1 mutants Homo sapiens
Signaling by high-kinase activity BRAF mutants Homo sapiens
Signaling by moderate kinase activity BRAF mutants Homo sapiens
Signaling downstream of RAS mutants Homo sapiens
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:0080242 syndromic X-linked mental retardation Hough type
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025