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Poly [ADP-ribose] polymerase

Summary

UniProt ID

Q921K2

Gene Symbol

Parp1
Adprt1

Organism

Mus musculus (house mouse)

External Links

The O-GlcNAc Database: Q921K2
RaftProt: Q921K2

Annotation

Keyword

ADP-ribosylation
Allosteric enzyme
Chromosome
DNA repair
DNA-binding
Glycosyltransferase
NAD
Nucleotidyltransferase
Nucleus
Proteomics identification
Reference proteome
Repeat
Zinc-finger

Gene Ontology (GO)

Displaying entries **31 - 39** of 39 in total

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GO Term
protein auto-ADP-ribosylation
cellular response to zinc ion
replication fork reversal
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of single strand break repair
cellular response to amyloid-beta
regulation of base-excision repair
positive regulation of double-strand break repair via homologous recombination
negative regulation of cGAS/STING signaling pathway

Displaying **all 9** entries
GO Term
nuclear replication fork
mitochondrion
cytosol
transcription regulator complex
nuclear body
site of double-strand break
chromatin
nuclear envelope
nucleolus

Displaying entries **1 - 10** of 20 in total

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GO Term
nucleosome binding
ubiquitin protein ligase binding
NAD DNA ADP-ribosyltransferase activity
protein homodimerization activity
transcription regulator activator activity
damaged DNA binding
NAD+ ADP-ribosyltransferase activity
nucleotidyltransferase activity
zinc ion binding
histone deacetylase binding

Annotation information from UniProt.

Sequence

MAEASERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRQPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFLAEYAKSNRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSKKGKDKDSSKLEKALKAQNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPESSAPAPLALPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGSANKASLCISTKKEVEKMSKKMEEVKAANVRVVCEDFLQDVSASTKSLQELLSAHSLSSWGAEVKAEPGEVVAPKGKSAAPSKKSKGAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAVEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGTKSKLPKPVQELVGMIFDVESMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSASITLEGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites