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Insulin-like receptor

Summary

UniProt ID: Q93105
Gene Symbol: InR AAEL002317
Gene ID
Organism: Aedes aegypti (yellow fever mosquito)

External Links

Re-Glyco: Q93105

Annotation

Keyword: ATP-binding Cleavage on pair of basic residues Disulfide bond Glycoprotein Manganese Metal-binding Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
nervous system development
insulin receptor signaling pathway	ISS	GO_REF
cell differentiation	IEA	GO_REF
glucose homeostasis	IEA	GO_REF
positive regulation of MAPK cascade	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

animal gross anatomical part developmental process [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

Displaying **all 2** entries
GO Term	Evidence Code	Reference
insulin receptor complex	IEA	GO_REF
axon	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

insulin receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

insulin receptor complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

insulin receptor complex

cellular anatomical structure [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
insulin receptor activity	ISS	GO_REF
insulin receptor activity	IEA	GO_REF
ATP binding	IEA	GO_REF
phosphatidylinositol 3-kinase binding	ISS	GO_REF
phosphatidylinositol 3-kinase binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

hormone binding [inference]

peptide hormone binding [inference]

insulin binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

insulin receptor activity

protein-hormone receptor activity [inference]

insulin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVSLLLFSILVVPVAVVQGDEMKAGQVGPVPKGGVCGSVDVRNSPAHLDRLKDCVVVEGFVHILLIDKYIDSSFENYSFPLLTEITEYLLLFRVNGLKSLRRLFPNLAVIRGDALVGDYAMVIYELMHIEEIGLISLMDITRGGVRIEKNPKLCFANTIDWKAMTVPGTNNYIKDNQKDNVCPICPAESTAVMLPNGSKQKCPAAPVRGGNKDHKRTLCWNANHCQTICPPECPKACSKTGVCCDAESCLGGCNLPNTSSCSVCRHLSIDPAGKRQCVAKCPPNTFKYHTRCVTRDECYAMKKPISLDSNPDLPDQPFIPHNGSCLMECPLDHELITELNKTRWCRKCSGTCPKRCEGSNIDNIQSAQLLKGCEIIDGSLEIQLRSRGGENIVKELENFLSSITEIKGYLKVVRSYPLLSLGFLKKLKIIHGKGNKVSNSSLYVVENQNLQELFDHNVTIGEGKLFFFNNPMLCTDRIKAVKKYNPGIEIENESQLESNNGDRAACSITELETSLKSIGSETAIIQWAPFTELSDARMLLGYVIYYIEAPYANVTFFDGRDACNTEGWRLDDISDFNMDKETTKILTQLKPYTQYAYYVKTYTLGSEGLGGQSKIKYFTTAPGTPSVVRDVEVSVNKNMLTVKWLPPLKMNGRLKEYEVFIELNADDNEQLMLRDYCEDDKLRDIVPETPTSAPPPKTSICTADQCRNYCKAPTSGGSTGTIDVTDKENQITFEDQLHNYVYIKNPLLRDKTTRRKRSTNLLFPNNTENKKNDTTDRRTEKVKDEPYYQYIFNATNETSITFPLSYFNHYSLYVFKIRACRHPGDPPAPSVRLVDVELACGNEVFENFRTPKKEGADDIPPESILIEEQSNNTQRQIRVQWKEPSKPNGPIVKFVVKYQRVDLESVSSTDICIRYSSFNQTRGALLTKLEPGNYSIRVMATTIAGDGAPSAARYVLIAKDDSMGTTLIWLGTLIVIFLCSVGFVAFYWYKYRYMSKQIRMYPEVNPDYAGVQYKVDDWEVERNHIIQLEELGQGSFGMVYKGILTQLRGEKCNQPCAIKTVNESATAREKDSFLLEASVMKQFNTHHVVRLLGVVSQGDPTLVIMELMANGDLKSYLRRHRPDYENGEDPSPQPPTLRQIIQMAIEIADGMAYLSAKKFVHRDLAARNCMVADDMTVKIGDFGMTRDIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTNDQVLRYVIDGGVMERPENCPDNLYNLMRRCWQHRPTARPTFMEIISELLPDASPHFQDVAFYNSQDALDMLRGQHQTVIIDEATTPLRPGDDHDEEPGEDDDLVGHGEGHIGDVGTDDEFSMEMTNSHLVRNNGPMATIRSPHSPLR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 16 in total

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Position	Description	Source
76	N-linked (GlcNAc...) asparagine	UniProt
196	N-linked (GlcNAc...) asparagine	UniProt
257	N-linked (GlcNAc...) asparagine	UniProt
322	N-linked (GlcNAc...) asparagine	UniProt
340	N-linked (GlcNAc...) asparagine	UniProt
439	N-linked (GlcNAc...) asparagine	UniProt
457	N-linked (GlcNAc...) asparagine	UniProt
492	N-linked (GlcNAc...) asparagine	UniProt
553	N-linked (GlcNAc...) asparagine	UniProt
765	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements