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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Sialidase-1
Summary
- UniProt ID
- Q99519
- Gene Symbol
-
- NEU1
- NANH
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0012514
- GlyConnect
- GlyGen
- Q99519
- PubChem
- Q99519
- The Human Metabolome Database
- HMDBP00323
Annotation
- Keyword
-
- Carbohydrate metabolism
- Cell membrane
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Glycosidase
- Lipid degradation
- Lysosome
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| ganglioside catabolic process |
| oligosaccharide catabolic process |
| GO Term |
|---|
| extracellular region |
| cytoplasm |
| lysosome |
| lysosomal membrane |
| plasma membrane |
| membrane |
| intracellular membrane-bounded organelle |
| cell junction |
| extracellular exosome |
| specific granule lumen |
Sequence
MTGERPSTALPDRRWGPRILGFWGGCRVWVFAAIFLLLSLAASWSKAENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 186 | N-linked (GlcNAc...) asparagine | |||
| 343 | N-linked (GlcNAc...) asparagine |
|
||
| 352 | N-linked (GlcNAc...) asparagine | |||
|
|
|
G85282JO
G45395BF
G49642SA
G40574BA
G08918WF
G00912UN
G87661QW
G83646BJ
G27058EU
G41071NU
G59626AS
G65184UU
G42124LM
G90659AW
G62765YT
G64527OM
G72790NZ
G95177YH
G10486CT
G05049YU
G31852PQ
G49955PK
G72787SB
G23719VF
G41247ZX
G35029YA
G92275SC
G28681TP
G37995HC
G15664MX
G80920RR
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective NEU1 causes sialidosis | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Sialic acid metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060249 | scoliosis | |
| DOID:0060320 | inguinal hernia | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0080502 | GM1 gangliosidosis type 1 | |
| DOID:0080540 | galactosialidosis | |
| DOID:0110035 | Alzheimer's disease 2 | |
| DOID:0110037 | Alzheimer's disease 5 | |
| DOID:0110038 | Alzheimer's disease 6 | |
| DOID:0110039 | Alzheimer's disease 7 |
