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Pituitary homeobox 2

Summary

UniProt ID

Q99697

Gene Symbol

ARP1
PITX2
RGS
RIEG
RIEG1

Gene ID

5308

Organism

Homo sapiens (human)

External Links

GlyGen: Q99697
PubChem: Q99697
Re-Glyco: Q99697

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA-binding
Developmental protein
Disease variant
Homeobox
Nucleus
Peters anomaly
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
chromatin
nucleus
cytoplasm
nucleoplasm
transcription regulator complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 19 in total

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GO Term
prolactin secreting cell differentiation
deltoid tuberosity development
somatotropin secreting cell differentiation
iris morphogenesis
negative regulation of transcription by RNA polymerase II
outflow tract morphogenesis
regulation of transcription by RNA polymerase II
determination of left/right symmetry
camera-type eye development
embryonic heart tube left/right pattern formation

Displaying entries **1 - 10** of 12 in total

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GO Term
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription factor activity
identical protein binding
protein homodimerization activity
phosphoprotein binding
RNA polymerase II-specific DNA-binding transcription factor binding
DNA-binding transcription factor binding
transcription cis-regulatory region binding
DNA-binding transcription repressor activity, RNA polymerase II-specific

Annotation information from UniProt.

Sequence

METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPESRKEAASSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
259				GlyGen
268				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
TFAP2 (AP-2) family regulates transcription of other transcription factors	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050647	Arts syndrome	Alliance of Genome Resources
DOID:0080609	anterior segment dysgenesis 4	Alliance of Genome Resources
DOID:0110120	Axenfeld-Rieger syndrome type 1	Alliance of Genome Resources
DOID:0111548	ring dermoid of cornea	Alliance of Genome Resources
DOID:14686	Axenfeld-Rieger syndrome	Alliance of Genome Resources