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ATP-dependent RNA helicase DHX58

Summary

UniProt ID

Q99J87

Gene Symbol

Dhx58
D11lgp2e
Lgp2

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q99J87
The O-GlcNAc Database: Q99J87
RaftProt: Q99J87
O-GlcNAcAtlas: Q99J87

Annotation

Keyword

Antiviral defense
Coiled coil
Cytoplasm
Helicase
Innate immunity
Metal-binding
RNA-binding
Reference proteome
Zinc

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

1

2

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GO Term
cytoplasmic pattern recognition receptor signaling pathway
response to virus
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
antiviral innate immune response
positive regulation of MDA-5 signaling pathway
positive regulation of RIG-I signaling pathway
response to bacterium
negative regulation of innate immune response
negative regulation of type I interferon production

Displaying 1 entry
GO Term
cytoplasm

Displaying **all 7** entries
GO Term
DNA binding
RNA helicase activity
double-stranded RNA binding
single-stranded RNA binding
ATP binding
zinc ion binding
ATP hydrolysis activity

Annotation information from UniProt.

Sequence

MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDRGKVVVLVNRVHLVSQHAEEFRRMLDKHWTVTTLSGDMGSRAGFGLMARSHDLLICTAELLQLALNSSEEDEHVELREFSLIVVDECHHTHKDTVYNTILSRYLEQKLKKAEPLPQVLGLTASPGTGGATKLQGAIDHILQLCANLDTCHIMSPKNCYSQLLMHNPKPCKQYDLCQRRAQDPFGDLIKKLMNQIHQQLEMPDLKQQFGTQMYEQQVVQLCKDAAEAGLQEQRVYALHLRRYNDALFIHDTVRARDALDMLQDFYDRERTTKTQMVRAESWLLKLFDDHKNVLGQLAARGPENPKLEMLERILLKQFGSPGHTRGIIFTRTRQTASSLLLWLRQQPCLQTVGIKPQMLIGAGNTSQSTHMTQKDQQEVIQEFRDGILSLLVATSVAEEGLDIAQCNVVVRYGLLTNEISMVQARGRARAGQSVYSFLATEGSREMKRELTNEALEVLMEKAVAAVQKMDPDEFKAKIRDLQQASLVKRAARAAHREIQQGQFLPEHVQLLCINCMVAVGYGSDLRKVEGTHHVNVNPNFSVYYTTSQNPVVINKVFKDWRPGGTIRCSNCGEVWGFQMIYKSVTLPVLKIGSILLETPRGKIQAKKWSRVPFSIPVFDILQDCTQSLSELSLD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites