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Triggering receptor expressed on myeloid cells 2

Summary

UniProt ID

Q99NH8

Gene Symbol

Trem2
Trem2a
Trem2b
Trem2c

Organism

Mus musculus (house mouse)

External Links

PubChem: Q99NH8

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Lipid-binding
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
negative regulation of inflammatory response to antigenic stimulus
phagocytosis, recognition
phagocytosis, engulfment
microglial cell activation
positive regulation of protein phosphorylation
microglial cell activation involved in immune response
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
memory
regulation of gene expression
positive regulation of gene expression

Displaying **all 4** entries
GO Term
extracellular region
plasma membrane
plasma membrane raft
cell surface

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GO Term
transmembrane signaling receptor activity
signaling receptor activity
kinase activator activity
very-low-density lipoprotein particle binding
peptidoglycan binding
protein tyrosine kinase binding
lipopolysaccharide binding
amyloid-beta binding
phosphatidylserine binding
phospholipid binding

Annotation information from UniProt.

Sequence

MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
20	N-linked (GlcNAc...) asparagine			UniProt
79	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
DAP12 interactions	Mus musculus
DAP12 signaling	Mus musculus
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mus musculus
Other semaphorin interactions	Mus musculus