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Triggering receptor expressed on myeloid cells 2

Summary

UniProt ID

Q99NH8

Gene Symbol

Trem2
Trem2a
Trem2b
Trem2c

Gene ID

83433

Organism

Mus musculus (house mouse)

External Links

PubChem: Q99NH8
Re-Glyco: Q99NH8

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Lipid-binding
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
plasma membrane raft
extracellular region
plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
regulation of lipid metabolic process
osteoclast differentiation
social behavior
defense response to bacterium
negative regulation of apoptotic process
cellular response to oxidised low-density lipoprotein particle stimulus
complement-mediated synapse pruning
amyloid-beta clearance by cellular catabolic process
positive regulation of amyloid-beta clearance
positive regulation of engulfment of apoptotic cell

Displaying entries **1 - 10** of 20 in total

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GO Term
transmembrane signaling receptor activity
signaling receptor activity
lipopolysaccharide binding
peptidoglycan binding
high-density lipoprotein particle binding
apolipoprotein A-I binding
lipoteichoic acid binding
sulfatide binding
amyloid-beta binding
phospholipid binding

Annotation information from UniProt.

Sequence

MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
20	N-linked (GlcNAc...) asparagine			UniProt
79	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
DAP12 interactions	Mus musculus
DAP12 signaling	Mus musculus
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mus musculus
Other semaphorin interactions	Mus musculus