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Triggering receptor expressed on myeloid cells 2

Summary

UniProt ID

Q99NH8

Gene Symbol

Trem2
Trem2a
Trem2b
Trem2c

Organism

Mus musculus (house mouse)

External Links

PubChem: Q99NH8

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Lipid-binding
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix

Gene Ontology (GO)

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GO Term
positive regulation of ATP biosynthetic process
positive regulation of chemotaxis
dendritic cell differentiation
import into cell
positive regulation of establishment of protein localization
regulation of plasma membrane bounded cell projection organization
regulation of cytokine production involved in inflammatory response
negative regulation of cytokine production involved in inflammatory response
regulation of intracellular signal transduction
microglial cell activation involved in immune response

Displaying **all 4** entries
GO Term
cell surface
extracellular region
plasma membrane
plasma membrane raft

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GO Term
high-density lipoprotein particle binding
apolipoprotein A-I binding
lipoteichoic acid binding
sulfatide binding
amyloid-beta binding
phosphatidylserine binding
phospholipid binding
semaphorin receptor activity
low-density lipoprotein particle binding
semaphorin receptor binding

Annotation information from UniProt.

Sequence

MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
20	N-linked (GlcNAc...) asparagine			UniProt
79	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
DAP12 interactions	Mus musculus
DAP12 signaling	Mus musculus
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mus musculus
Other semaphorin interactions	Mus musculus