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Serine/threonine-protein kinase/endoribonuclease IRE1
Summary
- UniProt ID
- Q9EQY0
- Gene Symbol
-
- Ern1
- Ire1
- Organism
- Mus musculus (house mouse)
External Links
- PubChem
- Q9EQY0
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ATP-binding
- Alternative splicing
- Apoptosis
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Hydrolase
- Magnesium
- Metal-binding
- Multifunctional enzyme
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Signal
- Transcription regulation
- Transmembrane helix
- Unfolded protein response
- Gene Ontology (GO)
| GO Term |
|---|
| AIP1-IRE1 complex |
| IRE1-TRAF2-ASK1 complex |
| IRE1-RACK1-PP2A complex |
| mitochondrion |
| endoplasmic reticulum membrane |
| nuclear inner membrane |
| GO Term |
|---|
| protein serine/threonine kinase activity |
| enzyme binding |
| Hsp90 protein binding |
| Hsp70 protein binding |
| protein homodimerization activity |
| unfolded protein binding |
| magnesium ion binding |
| endonuclease activity |
| RNA endonuclease activity |
| ADP binding |
Sequence
MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKRSFEEVINIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSVHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDPEFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTYYWHEPTEPQPPVIPYAL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 178 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| IRE1alpha activates chaperones | Mus musculus |
