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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Summary
- UniProt ID
- Q9H3H5
- Gene Symbol
-
- DPAGT1
- DPAGT2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9H3H5
- PubChem
- Q9H3H5
- The Human Metabolome Database
- HMDBP01096
- The O-GlcNAc Database
- Q9H3H5
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Congenital disorder of glycosylation
- Congenital myasthenic syndrome
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Glycosyltransferase
- Magnesium
- Metal-binding
- Reference proteome
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| protein N-linked glycosylation |
| UDP-N-acetylglucosamine metabolic process |
| dolichol-linked oligosaccharide biosynthetic process |
| GO Term |
|---|
| endoplasmic reticulum membrane |
| membrane |
| intracellular membrane-bounded organelle |
Sequence
MWAFSELPMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITFSIRYQLVRLFYDV
Glycosylation Sites
G83460ZZ
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | Homo sapiens |
| Defective DPAGT1 causes CDG-1j, CMSTA2 | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10763 | hypertension | |
| DOID:0050214 | Lambert-Eaton myasthenic syndrome | |
| DOID:0050570 | congenital disorder of glycosylation type I | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060243 | stuttering | |
| DOID:0060249 | scoliosis | |
| DOID:0060260 | ptosis | |
| DOID:0060261 | congenital ptosis | |
| DOID:0060823 | syndromic X-linked intellectual disability 94 | |
| DOID:0080070 | mucolipidosis II alpha/beta |
