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GDP-fucose protein O-fucosyltransferase 1
Summary
- UniProt ID
- Q9H488
- Gene Symbol
-
- POFUT1
- FUT12
- KIAA0180
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- Q9H488
- PubChem
- Q9H488
- The Human Metabolome Database
- HMDBP08846
- The O-GlcNAc Database
- Q9H488
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Disulfide bond
- Endoplasmic reticulum
- Fucose metabolism
- Glycoprotein
- Glycosyltransferase
- Manganese
- Notch signaling pathway
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| protein O-linked fucosylation |
| GO Term |
|---|
| membrane |
| endoplasmic reticulum |
| GO Term |
|---|
| peptide-O-fucosyltransferase activity |
| fucosyltransferase activity |
Sequence
MGAAAWARPLSVSFLLLLLPLPGMPAGSWDPAGYLLYCPCMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRVISLEDFMEKLAPTHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFNKSELFTGISFSASYREQWSQRFSPKEHPVLALPGAPAQFPVLEEHRPLQKYMVWSDEMVKTGEAQIHAHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTAAPLTMTMCLPDLKEIQRAVKLWVRSLDAQSVYVATDSESYVPELQQLFKGKVKVVSLKPEVAQVDLYILGQADHFIGNCVSSFTAFVKRERDLQGRPSSFFGMDRPPKLRDEF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 62 | N-linked (GlcNAc...) asparagine |
|
||
| 160 | N-linked (GlcNAc...) asparagine | |||
|
|
G07246CJ
G78787DI
G27915IV
G70441OD
G24528MX
G41071NU
G72747WU
G92406TI
G59924QI
G88891KO
G05049YU
G90575OW
G02815KT
G06110VR
G37995HC
G84225JN
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Pre-NOTCH Processing in the Endoplasmic Reticulum | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060256 | Dowling-Degos disease | |
| DOID:0060258 | reticulate acropigmentation of Kitamura | |
| DOID:0060262 | gallbladder disease | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:10907 | microcephaly | |
| DOID:11843 | coronary artery anomaly | |
| DOID:11847 | coronary thrombosis | |
| DOID:1324 | lung cancer | |
| DOID:1325 | bronchus cancer | |
| DOID:1612 | breast cancer |
