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Electrogenic sodium bicarbonate cotransporter 1
Summary
- UniProt ID
- Q9JI66
- Gene Symbol
- Slc4a4 Nbc Nbc1 Nbce1 Rnbc1
- Gene ID
- 84484
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Alternative splicing Cell membrane Phosphoprotein Reference proteome Sodium transport Symport Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| sodium ion transport | ||
| sodium ion transport | ||
| regulation of pH | ||
| regulation of pH | ||
| bicarbonate transport |
GO Hierarchy
biological process
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| cytosol |
|
|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| cell surface |
| GO Term | Evidence Code | Reference |
|---|---|---|
| solute:inorganic anion antiporter activity | ||
| monoatomic anion transmembrane transporter activity | ||
| sodium:bicarbonate symporter activity | ||
| sodium:bicarbonate symporter activity | ||
| sodium:bicarbonate symporter activity |
- Site Annotations
| Position | Description |
|---|---|
| 636 | Not glycosylated |
Sequence
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKAGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFSNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHSFDYLEFRLWIGLWSAFMCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFRVGYNTHFSCACLPPDPVNLSVSNDTTLAPEDLPTVSSTDMYHNATFDWAYLSKKECVKFGGKLVGNNCDFVPDITLMSFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPHRGWFVPPFGGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTSLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDITEQQPFLSDNKPLDRERSSTFLERHTSC
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Bicarbonate transporters | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12387 | nephrogenic diabetes insipidus |
