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Thioredoxin reductase 1, cytoplasmic

Summary

UniProt ID: Q9JMH6
Gene Symbol: Txnrd1 Trxr1
Gene ID: 50493
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q9JMH6
PubChem: Q9JMH6
Re-Glyco: Q9JMH6

Annotation

Keyword: Alternative splicing Cytoplasm Disulfide bond FAD NADP Oxidoreductase Phosphoprotein Redox-active center Reference proteome Selenocysteine Ubl conjugation

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
mesoderm formation	IMP	PMID
response to oxidative stress	ISO	GO_REF
gastrulation	IMP	PMID
cell population proliferation	IMP	PMID
obsolete selenocysteine metabolic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

hydrogen peroxide catabolic process

benzene-containing compound metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cell population proliferation

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

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GO Term	Evidence Code	Reference
fibrillar center	ISO	GO_REF
nucleus	ISO	GO_REF
nucleus	IDA	PMID
nucleoplasm	ISO	GO_REF
nucleoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
thioredoxin-disulfide reductase (NADPH) activity	ISS	GO_REF
thioredoxin-disulfide reductase (NADPH) activity	ISO	GO_REF GO_REF
thioredoxin-disulfide reductase (NADPH) activity	IDA	PMID
thioredoxin-disulfide reductase (NADPH) activity	IEA	GO_REF GO_REF GO_REF GO_REF
NAD(P)H oxidase H2O2-forming activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity [inference]

protein-disulfide reductase [NAD(P)H] activity [inference]

thioredoxin-disulfide reductase (NADPH) activity

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [inference]

protein-disulfide reductase [NAD(P)H] activity [inference]

thioredoxin-disulfide reductase (NADPH) activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

NADPH peroxidase activity

selenate reductase activity

catalytic activity, acting on a protein [inference]

protein-disulfide reductase activity [inference]

protein-disulfide reductase [NAD(P)H] activity [inference]

thioredoxin-disulfide reductase (NADPH) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

mercury ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

antioxidant activity [inference]

peroxidase activity [inference]

NADPH peroxidase activity

thioredoxin-disulfide reductase (NADPH) activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPVDDCWLYFPASRGRTFVQTVWVAPTCPNCCWFPGFLPPVPRPPHVPRVLLRGPRGAVLPASRPSKTLPSSSQTPCPTDPCICPPPSTPDSRQEKNTQSELPNKKGQLQKLPTMNGSKDPPGSYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALKDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGDILQSGCUG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
27				GlyGen
79				GlyGen
89				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Detoxification of Reactive Oxygen Species	Mus musculus
Interconversion of nucleotide di- and triphosphates	Mus musculus
Metabolism of ingested MeSeO2H into MeSeH	Mus musculus
TP53 Regulates Metabolic Genes	Mus musculus

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Acknowledgements