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Ferroportin

Summary

UniProt ID

Q9NP59

Gene Symbol

FPN
FPN1
IREG1
MSTP079
SLC11A3
SLC40A1

Gene ID

30061

Organism

Homo sapiens (human)

External Links

GlyGen: Q9NP59
PubChem: Q9NP59
The Human Metabolome Database: HMDBP02321
Re-Glyco: Q9NP59

Annotation

Keyword

3D-structure
Cell membrane
Disease variant
Glycoprotein
Iron transport
Metal-binding
Reference proteome
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
nucleoplasm
cytosol
basolateral plasma membrane
synaptic vesicle
cytoplasm
plasma membrane
membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 12 in total

1

2

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GO Term
establishment of localization in cell
positive regulation of transcription by RNA polymerase II
lymphocyte homeostasis
intracellular iron ion homeostasis
iron ion transmembrane transport
multicellular organismal-level iron ion homeostasis
endothelium development
apoptotic process
negative regulation of apoptotic process
transcription by RNA polymerase II

Displaying **all 5** entries
GO Term
iron ion transmembrane transporter activity
ferrous iron transmembrane transporter activity
peptide hormone binding
metal ion binding
identical protein binding

Annotation information from UniProt.

Sequence

MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
434	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Defective CP causes aceruloplasminemia (ACERULOP)	Homo sapiens
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	Homo sapiens
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	Homo sapiens
Iron uptake and transport	Homo sapiens
Metal ion SLC transporters	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111028	hemochromatosis type 4	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements