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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Neutral ceramidase
Summary
- UniProt ID
- Q9NR71
- Gene Symbol
-
- ASAH2
- HNAC1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9NR71
- PubChem
- Q9NR71
- SwissLipids
- The Human Metabolome Database
- HMDBP09165
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Apoptosis
- Calcium
- Cell membrane
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Hydrolase
- Metal-binding
- Mitochondrion
- Phosphoprotein
- Reference proteome
- Secreted
- Signal-anchor
- Sphingolipid metabolism
- Transmembrane helix
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular exosome |
| mitochondrion |
| caveola |
| Golgi membrane |
| extracellular region |
| Golgi apparatus |
| plasma membrane |
| GO Term |
|---|
| zinc ion binding |
| ceramidase activity |
| N-acylsphingosine amidohydrolase activity |
| calcium ion binding |
Sequence
MAKRTFSNLETFLIFLLVMMSAITVALLSLLFITSGTIENHKDLGGHFFSTTQSPPATQGSTAAQRSTATQHSTATQSSTATQTSPVPLTPESPLFQNFSGYHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPAVILSFEGTSPAFEVVTI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 62 | O-linked (GalNAc...) threonine |
|
||
| 67 | O-linked (GalNAc...) serine |
|
||
| 68 | O-linked (GalNAc...) threonine |
|
||
| 70 | O-linked (GalNAc...) threonine |
|
||
| 73 | O-linked (GalNAc...) serine |
|
||
| 74 | O-linked (GalNAc...) threonine |
|
||
| 76 | O-linked (GalNAc...) threonine |
|
||
| 78 | O-linked (GalNAc...) serine |
|
||
| 79 | O-linked (GalNAc...) serine |
|
||
| 80 | O-linked (GalNAc...) threonine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Glycosphingolipid catabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0060125 | heavy chain disease | |
| DOID:0060127 | gamma heavy chain disease | |
| DOID:0060262 | gallbladder disease | |
| DOID:0060707 | lymphoproliferative syndrome 1 | |
| DOID:0060708 | lymphoproliferative syndrome 2 | |
| DOID:0070324 | systemic Epstein-Barr virus positive T-cell lymphoma of childhood | |
| DOID:0110115 | autoimmune lymphoproliferative syndrome type 2A | |
| DOID:0110116 | autoimmune lymphoproliferative syndrome type 2B | |
| DOID:0110119 | autoimmune lymphoproliferative syndrome type 3 |
