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Dual oxidase 2

Summary

UniProt ID

Q9NRD8

Gene Symbol

DUOX2
LNOX2
THOX2

Organism

Homo sapiens (human)

External Links

GlyGen: Q9NRD8
PubChem: Q9NRD8
The Human Metabolome Database: HMDBP03091
The O-GlcNAc Database: Q9NRD8
O-GlcNAcAtlas: Q9NRD8

Annotation

Keyword

Calcium
Cell junction
Cell membrane
Congenital hypothyroidism
Disease variant
Disulfide bond
FAD
Glycoprotein
Hydrogen peroxide
Metal-binding
NADP
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

1

2

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GO Term
positive regulation of wound healing
positive regulation of cell motility
response to cAMP
response to virus
cuticle development
hydrogen peroxide biosynthetic process
hydrogen peroxide catabolic process
thyroid hormone generation
defense response
response to oxidative stress

Displaying **all 10** entries
GO Term
plasma membrane
anchoring junction
cell leading edge
extracellular exosome
apical plasma membrane
apical part of cell
cytosol
NADPH oxidase complex
endoplasmic reticulum
cell surface

Displaying **all 7** entries
GO Term
calcium ion binding
NADH oxidase H202-forming activity
NADPH oxidase H202-forming activity
NAD(P)H oxidase H2O2-forming activity
heme binding
peroxidase activity
superoxide-generating NAD(P)H oxidase activity

Annotation information from UniProt.

Sequence

MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	GlyTouCan ID	Source
100	N-linked (GlcNAc...) asparagine		UniProt GlyGen
348	N-linked (GlcNAc...) asparagine		UniProt GlyGen
382	N-linked (GlcNAc...) asparagine		UniProt GlyGen
455	N-linked (GlcNAc...) asparagine		UniProt GlyGen
537	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1299		G49108TO	GlyGen The O-GlcNAc Database