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NAD-dependent protein deacylase sirtuin-5, mitochondrial

Summary

UniProt ID

Q9NXA8

Gene Symbol

SIRT5
SIR2L5

Organism

Homo sapiens (human)

External Links

GlyGen: Q9NXA8
PubChem: Q9NXA8
The Human Metabolome Database: HMDBP08883
The O-GlcNAc Database: Q9NXA8

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Metal-binding
Mitochondrion
NAD
Nucleus
Reference proteome
Transferase
Transit peptide
Zinc

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

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2

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GO Term
response to nutrient levels
negative regulation of reactive oxygen species metabolic process
protein deglutarylation
mitochondrion organization
protein deacetylation
regulation of ketone biosynthetic process
negative regulation of cardiac muscle cell apoptotic process
protein demalonylation
peptidyl-lysine demalonylation
protein desuccinylation

Displaying **all 5** entries
GO Term
nucleus
mitochondrion
mitochondrial matrix
cytosol
mitochondrial intermembrane space

Displaying **all 8** entries
GO Term
protein-glutaryllysine deglutarylase activity
NAD-dependent histone deacetylase activity
NAD-dependent protein deacetylase activity
zinc ion binding
protein-malonyllysine demalonylase activity
protein-succinyllysine desuccinylase activity
NAD+ binding
transferase activity

Annotation information from UniProt.

Sequence

MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites