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Toll-like receptor 4

Summary

UniProt ID

Q9QUK6

Gene Symbol

Tlr4
Lps

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0007644
GlyGen: Q9QUK6
PubChem: Q9QUK6

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Disease variant
Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **41 - 50** of **101** in total

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GO Term
positive regulation of MHC class II biosynthetic process
positive regulation of nitric oxide biosynthetic process
response to ethanol
positive regulation of macrophage cytokine production
ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to type II interferon

Displaying **all 10** entries
GO Term
early endosome
external side of plasma membrane
cell surface
perinuclear region of cytoplasm
plasma membrane
receptor complex
lipopolysaccharide receptor complex
phagocytic cup
ruffle
endosome membrane

Displaying **all 8** entries
GO Term
phosphatidylinositol 3-kinase binding
lipopolysaccharide binding
lipopolysaccharide immune receptor activity
signaling receptor binding
transmembrane signaling receptor activity
identical protein binding
protein heterodimerization activity
NAD+ nucleotidase, cyclic ADP-ribose generating

Annotation information from UniProt.

Sequence

MMPPWLLARTLIMALFFSCLTPGSLNPCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLVNVEQMTCATPVEMNTSLVLDFNNSTCYMYKTIISVSVVSVIVVSTVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNALLDGKASNPEQTAEEEQETATWT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
34	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
75	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
172	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
204	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
237	N-linked (GlcNAc...) asparagine	17803912	G62765YT	GlycoProtDB UniProt GlyGen
307	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
492	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
495	N-linked (GlcNAc...) asparagine			UniProt GlyGen
524	N-linked (GlcNAc...) asparagine	17803912		UniProt GlyGen
572	N-linked (GlcNAc...) asparagine	17803912	G50303LH	UniProt GlyGen