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Deoxyribonuclease-2-alpha

Summary

UniProt ID: Q9QZK8
Gene Symbol: Dnase2 Dnase2a Dnl2
Gene ID: 171575
Organism: Rattus norvegicus (Norway rat)

External Links

Re-Glyco: Q9QZK8

Annotation

Keyword: Apoptosis Developmental protein Disulfide bond Endonuclease Glycoprotein Lysosome Reference proteome Signal

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
DNA catabolic process	ISO	GO_REF
DNA catabolic process	IEA	GO_REF
apoptotic DNA fragmentation	IBA	GO_REF
enucleate erythrocyte differentiation
regulation of immune response

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

nucleic acid catabolic process [inference]

DNA catabolic process

apoptotic DNA fragmentation

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation [inference]

enucleate erythrocyte differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation [inference]

enucleate erythrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of response to stimulus [inference]

regulation of immune response

Displaying **all 3** entries
GO Term	Evidence Code	Reference
lysosome	ISS	GO_REF
lysosome	ISO	GO_REF
lysosome	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
endodeoxyribonuclease activity	IDA	PMID
DNA endonuclease activity	IDA	PMID
deoxyribonuclease II activity	ISS	GO_REF
deoxyribonuclease II activity	ISO	GO_REF
deoxyribonuclease II activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

endodeoxyribonuclease activity

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

deoxyribonuclease II activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAAPSSLLLAALLWVPAEALSCYGDSGRPVDWFVVYKLPANSGSGDKPWKGLMYKYMDQNSEGWQDGVGHIDSKDGAVGLTLQPLYQKNSSQLAFLLYNDQPPKSSSAQDSSSRGHTKGVLLLDQEGGFWLVHSVPRFPSPASSGAYSWPPNARTYGQTLLCVSLPFSQFPGIGKQLTYTYPLVYDHKLEGIFAQKLPDLEEVTKGHHVLREPWNSSVILTSRAGTTFQSFAKFGKFGDDLYSGWLAAALGTNLQVQFWPNSPGILPSNCSGTHKILDVTETGFPGPSGPTFNATEDHSKWCVAPEGPWVCVGDMNRNKRETHRGGGTLCTQVPALWKAFRSLVKACKPC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
89	N-linked (GlcNAc...) asparagine	UniProt
215	N-linked (GlcNAc...) asparagine	UniProt
269	N-linked (GlcNAc...) asparagine	UniProt
293	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Lysosome Vesicle Biogenesis	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements