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Guidelines
MIRAGE
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Summary
- UniProt ID
- Q9UBK2
- Gene Symbol
-
- LEM6
- PGC1
- PGC1A
- PPARGC1
- PPARGC1A
- Gene ID
- 10891
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative promoter usage
- Alternative splicing
- Biological rhythms
- Cytoplasm
- Nucleus
- Phosphoprotein
- RNA-binding
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleoplasm |
| cytosol |
| PML body |
| chromatin |
| nucleus |
Sequence
MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
Glycosylation Sites
G31852PQ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | Homo sapiens |
| Circadian Clock | Homo sapiens |
| FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | Homo sapiens |
| Heme signaling | Homo sapiens |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | Homo sapiens |
| PPARA activates gene expression | Homo sapiens |
| Regulation of MITF-M dependent genes involved in metabolism | Homo sapiens |
| Regulation of RUNX2 expression and activity | Homo sapiens |
| SUMOylation of transcription cofactors | Homo sapiens |
| Transcriptional activation of mitochondrial biogenesis | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:12858 | Huntington's disease | |
| DOID:1287 | cardiovascular system disease | |
| DOID:14330 | Parkinson's disease | |
| DOID:1907 | malignant fibrous histiocytoma | |
| DOID:332 | amyotrophic lateral sclerosis | |
| DOID:4448 | macular degeneration | |
| DOID:9352 | type 2 diabetes mellitus |
