GlyCosmos Portal

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Klotho

Summary

UniProt ID

Q9UEF7

Gene Symbol

Organism

Homo sapiens (human)

External Links

GlyConnect

1435

GlyGen

Q9UEF7

PubChem

Q9UEF7

The Human Metabolome Database

HMDBP07765

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disease variant
Glycoprotein
Glycosidase
Hormone
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Vitamin D

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

1

2

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GO Term
positive regulation of bone mineralization
norepinephrine biosynthetic process
response to vitamin D
negative regulation of systemic arterial blood pressure
fibroblast growth factor receptor signaling pathway
determination of adult lifespan
response to activity
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
response to angiotensin
carbohydrate metabolic process

Displaying **all 6** entries
GO Term
extracellular region
extracellular space
plasma membrane
membrane
extracellular exosome
apical plasma membrane

Displaying **all 6** entries
GO Term
beta-glucuronidase activity
hormone activity
vitamin D binding
fibroblast growth factor receptor binding
beta-glucosidase activity
fibroblast growth factor binding

Annotation information from UniProt.

Sequence

MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	GlyTouCan ID	Source
106	N-linked (GlcNAc...) asparagine		UniProt GlyGen
115		G43417UB	GlyGen
159	N-linked (GlcNAc...) asparagine	G87661QW G83460ZZ G41071NU G47448YK G80920RR G62765YT	UniProt GlyGen GlyConnect
283	N-linked (GlcNAc...) asparagine		UniProt GlyGen
344	N-linked (GlcNAc...) asparagine		UniProt GlyGen
607	N-linked (GlcNAc...) asparagine		UniProt GlyGen
612	N-linked (GlcNAc...) asparagine		UniProt GlyGen
630			GlyGen
694	N-linked (GlcNAc...) asparagine		UniProt GlyGen