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Heparanase

Summary

UniProt ID

Q9Y251

Gene Symbol

HPSE
HEP
HPA
HPA1
HPR1
HPSE1
HSE1

Organism

Homo sapiens (human)

External Links

GlyGen: Q9Y251
PubChem: Q9Y251
The Human Metabolome Database: HMDBP02807

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Magnesium
Membrane
Nucleus
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 15 in total

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GO Term
proteoglycan metabolic process
response to organic substance
protein transmembrane transport
positive regulation of blood coagulation
heparin metabolic process
positive regulation of osteoblast proliferation
regulation of hair follicle development
positive regulation of hair follicle development
angiogenesis involved in wound healing
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

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GO Term
nucleoplasm
specific granule lumen
lysosomal lumen
extracellular matrix
intracellular membrane-bounded organelle
membrane raft
extracellular region
extracellular space
nucleus
lysosome

Displaying **all 3** entries
GO Term
heparanase activity
syndecan binding
beta-glucuronidase activity

Annotation information from UniProt.

Sequence

MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
162	N-linked (GlcNAc...) asparagine	14573609 28581485	G62765YT	UniProt GlyGen
178	N-linked (GlcNAc...) asparagine	14573609		UniProt GlyGen
200	N-linked (GlcNAc...) asparagine	14573609 28581485	G80920RR G73968GN G41247ZX G84225JN	UniProt GlyGen
217	N-linked (GlcNAc...) asparagine	14573609 16263699 19159218 28581485	G02815KT	UniProt GlyGen
238	N-linked (GlcNAc...) asparagine	14573609 19159218 28581485	G80920RR G31852PQ	UniProt GlyGen
456				GlyGen
459	N-linked (GlcNAc...) asparagine	14573609 28581485	G41247ZX	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
HS-GAG degradation	Homo sapiens
Neutrophil degranulation	Homo sapiens

Disease

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DO ID	Disease Name	Source
DOID:9312	chronic ethmoiditis	DisGeNET
DOID:934	viral infectious disease	DisGeNET DisGeNET
DOID:9351	diabetes mellitus	DisGeNET DisGeNET
DOID:9352	type 2 diabetes mellitus	DisGeNET DisGeNET
DOID:9408	acute myocardial infarction	DisGeNET DisGeNET
DOID:9452	steatotic liver disease	DisGeNET DisGeNET
DOID:9460	uterine corpus cancer	DisGeNET
DOID:9538	multiple myeloma	DisGeNET
DOID:9588	encephalitis	DisGeNET
DOID:9682	yellow fever	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements