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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Heparanase
Summary
- UniProt ID
- Q9Y251
- Gene Symbol
-
- HPSE
- HEP
- HPA
- HPA1
- HPR1
- HPSE1
- HSE1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9Y251
- PubChem
- Q9Y251
- The Human Metabolome Database
- HMDBP02807
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Calcium
- Cell adhesion
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Hydrolase
- Lysosome
- Magnesium
- Membrane
- Nucleus
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| nucleus |
| lysosome |
| lysosomal membrane |
| nucleoplasm |
| specific granule lumen |
| lysosomal lumen |
| extracellular matrix |
| intracellular membrane-bounded organelle |
| GO Term |
|---|
| heparanase activity |
| syndecan binding |
| beta-glucuronidase activity |
Sequence
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 162 | N-linked (GlcNAc...) asparagine | |||
| 178 | N-linked (GlcNAc...) asparagine |
|
||
| 200 | N-linked (GlcNAc...) asparagine | |||
| 217 | N-linked (GlcNAc...) asparagine | |||
| 238 | N-linked (GlcNAc...) asparagine | |||
| 456 |
|
|
||
| 459 | N-linked (GlcNAc...) asparagine |
G62765YT
G80920RR
G73968GN
G41247ZX
G84225JN
G02815KT
G31852PQ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110187 | Charcot-Marie-Tooth disease type 4K | |
| DOID:0110190 | Charcot-Marie-Tooth disease type 4B2 | |
| DOID:0110191 | Charcot-Marie-Tooth disease type 4B1 | |
| DOID:0110192 | Charcot-Marie-Tooth disease type 4H | |
| DOID:0110193 | Charcot-Marie-Tooth disease type 4F | |
| DOID:0110194 | Charcot-Marie-Tooth disease type 4B3 | |
| DOID:0110195 | Charcot-Marie-Tooth disease type 4E | |
| DOID:0110196 | Charcot-Marie-Tooth disease type 4G | |
| DOID:0110197 | Charcot-Marie-Tooth disease dominant intermediate B | |
| DOID:0110198 | Charcot-Marie-Tooth disease recessive intermediate C |
