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MIRAGE
Toll-like receptor 6

Summary
UniProt ID
Q9Y2C9
Gene Symbol
  • TLR6
Gene ID
10333
Organism
Homo sapiens (human)
GlyGen
Q9Y2C9
PubChem
Q9Y2C9
The Human Metabolome Database
HMDBP12384
Re-Glyco
Q9Y2C9
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Golgi apparatus
  • Inflammatory response
  • Innate immunity
  • Leucine-rich repeat
  • NAD
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 6 entries
GO Term
plasma membrane
receptor complex
Golgi apparatus
membrane raft
Toll-like receptor 2-Toll-like receptor 6 protein complex
phagocytic vesicle membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDVKS
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 9 entries
Position Description PubMed ID GlyTouCan ID Source
144 N-linked (GlcNAc...) asparagine
186 N-linked (GlcNAc...) asparagine
214 N-linked (GlcNAc...) asparagine
253 N-linked (GlcNAc...) asparagine
285 N-linked (GlcNAc...) asparagine
359 N-linked (GlcNAc...) asparagine
423 N-linked (GlcNAc...) asparagine
434 N-linked (GlcNAc...) asparagine
583 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 7 entries
Pathway Name Organism
ER-Phagosome pathway Homo sapiens
IRAK4 deficiency (TLR2/4) Homo sapiens
MyD88 deficiency (TLR2/4) Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane Homo sapiens
RSV-host interactions Homo sapiens
Regulation of TLR by endogenous ligand Homo sapiens
Toll Like Receptor TLR6:TLR2 Cascade Homo sapiens
Disease
Displaying all 5 entries
DO ID Disease Name Source
DOID:0060000 infective endocarditis
DOID:13564 aspergillosis
DOID:2841 asthma
DOID:399 tuberculosis
DOID:4483 rhinitis
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025