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Toll-like receptor 6

Summary

UniProt ID

Q9Y2C9

Gene Symbol

TLR6

Organism

Homo sapiens (human)

External Links

GlyGen: Q9Y2C9
PubChem: Q9Y2C9
The Human Metabolome Database: HMDBP12384
The O-GlcNAc Database: Q9Y2C9

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Golgi apparatus
Inflammatory response
Innate immunity
Leucine-rich repeat
NAD
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **21 - 29** of 29 in total

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GO Term
negative regulation of toll-like receptor 2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
detection of diacyl bacterial lipopeptide
cellular response to diacyl bacterial lipopeptide
cellular response to oxidised low-density lipoprotein particle stimulus
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of extrinsic apoptotic signaling pathway
cellular response to amyloid-beta

Displaying **all 6** entries
GO Term
Golgi apparatus
plasma membrane
receptor complex
phagocytic vesicle membrane
membrane raft
Toll-like receptor 2-Toll-like receptor 6 protein complex

Displaying **all 9** entries
GO Term
transmembrane signaling receptor activity
signaling receptor binding
signaling receptor activity
NAD+ nucleotidase, cyclic ADP-ribose generating
identical protein binding
protein heterodimerization activity
amyloid-beta binding
Toll-like receptor 2 binding
lipopeptide binding

Annotation information from UniProt.

Sequence

MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDVKS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	GlyTouCan ID	Source
144	N-linked (GlcNAc...) asparagine		UniProt GlyGen
186	N-linked (GlcNAc...) asparagine	G80920RR	UniProt GlyGen
214	N-linked (GlcNAc...) asparagine		UniProt GlyGen
253	N-linked (GlcNAc...) asparagine		UniProt GlyGen
285	N-linked (GlcNAc...) asparagine		UniProt GlyGen
359	N-linked (GlcNAc...) asparagine		UniProt GlyGen
423	N-linked (GlcNAc...) asparagine		UniProt GlyGen
434	N-linked (GlcNAc...) asparagine		UniProt GlyGen
583	N-linked (GlcNAc...) asparagine		UniProt GlyGen
		G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
ER-Phagosome pathway	Homo sapiens
IRAK4 deficiency (TLR2/4)	Homo sapiens
MyD88 deficiency (TLR2/4)	Homo sapiens
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Homo sapiens
RSV-host interactions	Homo sapiens
Regulation of TLR by endogenous ligand	Homo sapiens
Toll Like Receptor TLR6:TLR2 Cascade	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Annotation

International Collaboration

Acknowledgements