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Rap guanine nucleotide exchange factor 2

Summary

UniProt ID

Q9Y4G8

Gene Symbol

RAPGEF2
KIAA0313
NRAPGEP
PDZGEF1

Organism

Homo sapiens (human)

External Links

GlyGen: Q9Y4G8
PubChem: Q9Y4G8
The Human Metabolome Database: HMDBP01123
The O-GlcNAc Database: Q9Y4G8
O-GlcNAcAtlas: Q9Y4G8

Annotation

Keyword

3D-structure
Cell junction
Cell membrane
Cytoplasm
Developmental protein
Differentiation
Endosome
Epilepsy
GTPase activation
Guanine-nucleotide releasing factor
Neurogenesis
Phosphoprotein
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 37 in total

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GO Term
positive regulation of neuron projection development
cAMP-mediated signaling
ventricular system development
neuron projection development
Rap protein signal transduction
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
protein localization to plasma membrane
establishment of endothelial intestinal barrier
cellular response to nerve growth factor stimulus

Displaying entries **1 - 10** of 14 in total

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GO Term
late endosome
cytosol
apical plasma membrane
endocytic vesicle
perinuclear region of cytoplasm
cytoplasm
plasma membrane
cell-cell junction
membrane
protein-containing complex

Displaying **all 9** entries
GO Term
WW domain binding
guanyl-nucleotide exchange factor activity
GTPase activator activity
cAMP binding
diacylglycerol binding
PDZ domain binding
beta-1 adrenergic receptor binding
phosphatidic acid binding
calcium ion binding

Annotation information from UniProt.

Sequence

MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites