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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Cholesterol 24-hydroxylase
Summary
- UniProt ID
- Q9Y6A2
- Gene Symbol
-
- CYP46A1
- CYP46
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9Y6A2
- PubChem
- Q9Y6A2
- SwissLipids
- The Human Metabolome Database
- HMDBP05063
- The O-GlcNAc Database
- Q9Y6A2
- O-GlcNAcAtlas
- Q9Y6A2
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell projection
- Cholesterol metabolism
- Heme
- Microsome
- Monooxygenase
- Reference proteome
- Synapse
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| postsynapse |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| presynapse |
| dendrite |
| GO Term |
|---|
| heme binding |
| steroid hydroxylase activity |
| cholesterol 24-hydroxylase activity |
| testosterone 16-beta-hydroxylase activity |
| iron ion binding |
Sequence
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 83 |
|
|||
| 88 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Endogenous sterols | Homo sapiens |
| Synthesis of bile acids and bile salts via 24-hydroxycholesterol | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11870 | Pick's disease | |
| DOID:11949 | Creutzfeldt-Jakob disease | |
| DOID:12139 | dysthymic disorder | |
| DOID:12858 | Huntington's disease | |
| DOID:1289 | neurodegenerative disease | |
| DOID:14221 | abdominal obesity-metabolic syndrome 1 | |
| DOID:1443 | cerebral degeneration | |
| DOID:14525 | Reye syndrome | |
| DOID:1470 | major depressive disorder | |
| DOID:1595 | melancholic depression |
