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Disintegrin and metalloproteinase domain-containing protein 17

Summary

UniProt ID

Q9Z1K9

Gene Symbol

Adam17
Tace

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q9Z1K9

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 45 in total

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GO Term
germinal center formation
production of molecular mediator involved in inflammatory response
response to hypoxia
response to xenobiotic stimulus
Notch signaling pathway
defense response to Gram-positive bacterium
membrane protein ectodomain proteolysis
Notch receptor processing
positive regulation of G1/S transition of mitotic cell cycle
response to lipopolysaccharide

Displaying **all 8** entries
GO Term
cytoplasm
plasma membrane
actin cytoskeleton
membrane
apical plasma membrane
apical part of cell
membrane raft
cell surface

Displaying entries **1 - 10** of 12 in total

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GO Term
metal ion binding
SH3 domain binding
PDZ domain binding
endopeptidase activity
metalloendopeptidase activity
metallopeptidase activity
Notch binding
interleukin-6 receptor binding
integrin binding
tumor necrosis factor binding

Annotation information from UniProt.

Sequence

MRQRLLFLTTLVPFVLAPRPPEEPGSGSHLRLEKLDSLLSDYDILSLSNIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
157	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
452	N-linked (GlcNAc...) asparagine	UniProt
498	N-linked (GlcNAc...) asparagine	UniProt
539	N-linked (GlcNAc...) asparagine	UniProt
551	N-linked (GlcNAc...) asparagine	UniProt
606	N-linked (GlcNAc...) asparagine	UniProt