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Disintegrin and metalloproteinase domain-containing protein 17

Summary

UniProt ID

Q9Z1K9

Gene Symbol

Adam17
Tace

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q9Z1K9

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Gene Ontology (GO)

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GO Term
Notch signaling pathway
cell adhesion mediated by integrin
defense response to Gram-positive bacterium
positive regulation of G1/S transition of mitotic cell cycle
response to hypoxia
germinal center formation
production of molecular mediator involved in inflammatory response
proteolysis
cell adhesion
positive regulation of neuron projection development

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GO Term
cell surface
apical plasma membrane
apical part of cell
cytoplasm
plasma membrane
cell-cell junction
actin cytoskeleton
membrane
membrane raft
focal adhesion

Displaying entries **1 - 10** of 13 in total

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GO Term
SH3 domain binding
cytokine binding
metallodipeptidase activity
interleukin-6 receptor binding
PDZ domain binding
tumor necrosis factor binding
metalloendopeptidase activity involved in amyloid precursor protein catabolic process
Notch binding
metal ion binding
endopeptidase activity

Annotation information from UniProt.

Sequence

MRQRLLFLTTLVPFVLAPRPPEEPGSGSHLRLEKLDSLLSDYDILSLSNIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
157	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
452	N-linked (GlcNAc...) asparagine	UniProt
498	N-linked (GlcNAc...) asparagine	UniProt
539	N-linked (GlcNAc...) asparagine	UniProt
551	N-linked (GlcNAc...) asparagine	UniProt
606	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Regulated proteolysis of p75NTR	Rattus norvegicus
TNF signaling	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements