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Disintegrin and metalloproteinase domain-containing protein 17

Summary

UniProt ID

Q9Z1K9

Gene Symbol

Adam17
Tace

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q9Z1K9

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Notch signaling pathway
Phosphoprotein
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Gene Ontology (GO)

Displaying entries **41 - 45** of 45 in total

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GO Term
response to hypobaric hypoxia
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of epidermal growth factor receptor signaling pathway
germinal center formation
production of molecular mediator involved in inflammatory response

Displaying **all 8** entries
GO Term
cytoplasm
plasma membrane
actin cytoskeleton
membrane
apical plasma membrane
apical part of cell
membrane raft
cell surface

Displaying entries **11 - 12** of 12 in total

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GO Term
metallodipeptidase activity
metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Annotation information from UniProt.

Sequence

MRQRLLFLTTLVPFVLAPRPPEEPGSGSHLRLEKLDSLLSDYDILSLSNIQQHSIRKRDLQSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQSPKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNMAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSCKVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMDSASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGFEKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
157	N-linked (GlcNAc...) asparagine	UniProt
264	N-linked (GlcNAc...) asparagine	UniProt
452	N-linked (GlcNAc...) asparagine	UniProt
498	N-linked (GlcNAc...) asparagine	UniProt
539	N-linked (GlcNAc...) asparagine	UniProt
551	N-linked (GlcNAc...) asparagine	UniProt
606	N-linked (GlcNAc...) asparagine	UniProt