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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Insulin receptor
Summary
- UniProt ID
- P06213
- Gene Symbol
-
- INSR
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011401
- GlyConnect
- GlyGen
- P06213
- PubChem
- P06213
- The Human Metabolome Database
- HMDBP01521
- The O-GlcNAc Database
- P06213
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Carbohydrate metabolism
- Cell membrane
- Cleavage on pair of basic residues
- Diabetes mellitus
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endosome
- Glycoprotein
- Lysosome
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- S-nitrosylation
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Gene Ontology (GO)
| GO Term |
|---|
| lysosome |
| plasma membrane |
| insulin receptor complex |
| membrane |
| axon |
| dendrite membrane |
| receptor complex |
| extracellular exosome |
| caveola |
| endosome membrane |
| GO Term |
|---|
| phosphatidylinositol 3-kinase binding |
| protein tyrosine kinase activity |
| insulin receptor activity |
| cargo receptor activity |
| insulin binding |
| protein-containing complex binding |
Sequence
MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 698 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| IRS activation | Homo sapiens |
| Insulin receptor recycling | Homo sapiens |
| Insulin receptor signalling cascade | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
| Signal attenuation | Homo sapiens |
| Signaling by Insulin receptor | Homo sapiens |
