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Receptor tyrosine-protein kinase erbB-2

Summary

UniProt ID

P70424

Gene Symbol

Erbb2
Kiaa3023
Neu

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003777
PubChem: P70424

Annotation

Keyword

ATP-binding
Activator
Cell membrane
Cell projection
Cytoplasm
Disulfide bond
Endosome
Glycoprotein
Nucleus
Phosphoprotein
Receptor
Reference proteome
Signal
Transcription regulation
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

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GO Term
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
response to axon injury
semaphorin-plexin signaling pathway
phosphatidylinositol 3-kinase/protein kinase B signal transduction
estrous cycle
positive regulation of transcription by RNA polymerase I
positive regulation of Ras protein signal transduction
motor neuron axon guidance
positive regulation of MAPK cascade
positive regulation of Rho protein signal transduction

Displaying entries **11 - 20** of 22 in total

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GO Term
apical plasma membrane
lateral loop
cytosol
semaphorin receptor complex
nucleoplasm
endosome membrane
early endosome
basal plasma membrane
ruffle membrane
ERBB3:ERBB2 complex

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GO Term
Hsp90 protein binding
ubiquitin protein ligase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
RNA polymerase I core binding
ATP binding
coreceptor activity
growth factor binding
receptor tyrosine kinase binding

Annotation information from UniProt.

Sequence

MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVDAEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
125		22823882
531		22823882 23002422
572		22823882
630

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Downregulation of ERBB2 signaling	Mus musculus
Downregulation of ERBB2:ERBB3 signaling	Mus musculus
Drug-mediated inhibition of ERBB2 signaling	Mus musculus
ERBB2 Activates PTK6 Signaling	Mus musculus
ERBB2 Regulates Cell Motility	Mus musculus
GRB2 events in ERBB2 signaling	Mus musculus
GRB7 events in ERBB2 signaling	Mus musculus
PI3K events in ERBB2 signaling	Mus musculus
PI3K/AKT Signaling	Mus musculus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements