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Receptor tyrosine-protein kinase erbB-2

Summary

UniProt ID

P70424

Gene Symbol

Erbb2
Kiaa3023
Neu

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003777
PubChem: P70424

Annotation

Keyword

ATP-binding
Activator
Cell membrane
Cell projection
Cytoplasm
Disulfide bond
Endosome
Glycoprotein
Nucleus
Phosphoprotein
Receptor
Reference proteome
Signal
Transcription regulation
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

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GO Term
positive regulation of protein phosphorylation
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
peripheral nervous system development
heart development
neuromuscular junction development
positive regulation of cell population proliferation
positive regulation of gene expression
phosphorylation

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GO Term
basolateral plasma membrane
apical plasma membrane
lateral loop
cytosol
semaphorin receptor complex
nucleoplasm
endosome membrane
early endosome
basal plasma membrane
ruffle membrane

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GO Term
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein-containing complex binding
Hsp90 protein binding
ubiquitin protein ligase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
RNA polymerase I core binding
ATP binding

Annotation information from UniProt.

Sequence

MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVDAEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
125		22823882
531		22823882 23002422
572		22823882
630

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
RAF/MAP kinase cascade	Mus musculus
SHC1 events in ERBB2 signaling	Mus musculus
Sema4D induced cell migration and growth-cone collapse	Mus musculus
Signaling by ERBB2	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements