GlyCosmos Portal

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Ficolin-1

Summary

Organism: Homo sapiens (human)

External Links

UniProt: O00602
UniLectin: O00602

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Collagen
Direct protein sequencing
Disulfide bond
Glycoprotein
Innate immunity
Lectin
Metal-binding
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
complement activation, lectin pathway
recognition of apoptotic cell
negative regulation of viral entry into host cell
positive regulation of opsonization
proteolysis
G protein-coupled receptor signaling pathway
protein localization to cell surface
positive regulation of interleukin-8 production
cell surface pattern recognition receptor signaling pathway

Displaying **all 9** entries
GO Term
ficolin-1-rich granule lumen
serine-type endopeptidase complex
external side of plasma membrane
extracellular region
collagen trimer
extracellular space
plasma membrane
collagen-containing extracellular matrix
secretory granule lumen

Displaying **all 8** entries
GO Term
carbohydrate derivative binding
signaling receptor binding
carbohydrate binding
pattern recognition receptor activity
metal ion binding
G protein-coupled receptor binding
antigen binding
sialic acid binding

Annotation information from UniProt.

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Ficolins bind to repetitive carbohydrate structures on the target cell surface	Homo sapiens
Initial triggering of complement	Homo sapiens
Lectin pathway of complement activation	Homo sapiens
Neutrophil degranulation	Homo sapiens

UniLectin

UniProt
O00602

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).