GlyCosmos Portal

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Galectin-9

Summary

Lectin Name Aliases

Gal 9
Galectin-9
Human Galectin 9

Organism

Homo sapiens (human)

External Links

UniProt

O00182

LfDB

LfDB0274

UniLectin

O00182

CarboGrove

1031

Annotation

Keyword

3D-structure
Alternative splicing
Chemotaxis
Cytoplasm
Immunity
Lectin
Nucleus
Reference proteome
Repeat
Secreted

Gene Ontology (GO)

Displaying entries **1 - 10** of 44 in total

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GO Term
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
positive regulation of tumor necrosis factor production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
p38MAPK cascade
positive regulation of viral entry into host cell
positive regulation of NF-kappaB transcription factor activity
response to interleukin-1
positive regulation of non-canonical NF-kappaB signal transduction
positive regulation of dendritic cell chemotaxis

Displaying **all 5** entries
GO Term
cytosol
extracellular space
nucleus
cytoplasm
collagen-containing extracellular matrix

Displaying **all 5** entries
GO Term
galactose binding
galactoside binding
carbohydrate binding
disaccharide binding
enzyme binding

Annotation information from UniProt.

Reference

Displaying **all 10** entries
PubMed ID	Title	First Author
9038233	Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.	Wada J
16990264	Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.	Nagae M
18977853	Structural analysis of the recognition mechanism of poly-N-acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain.	Nagae M
19776007	Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.	Niki T
21187321	Galectin-9 regulates T helper cell function independently of Tim-3.	Su EW
23836896	Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.	Steelman AJ
25947381	Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION.	Lhuillier C
26582205	Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.	Nakakita S
28810662	Galectin-9 binds to O-glycans on protein disulfide isomerase.	Schaefer K
20861009	X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose.	Yoshida H

Pathway

Displaying 1 entry
Pathway Name	Organism
Interleukin-2 family signaling	Homo sapiens

UniLectin

UniProt
O00182

CarboGrove

Lectin Name: Human Galectin 9
Common Name: Gal 9

Automated Analysis report (Top 10 high affinity glycans)

Array Source

GHMO

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	9976.25	501.05
G87373RB	9016.75	295.6
G94393CX	5179.25	505.75
G48059CD	4141.75	104.13
G90411BS	3192.75	164.51
G63110FF	2671	215.1
G85278ER	2402.25	256.95
G79420BT	1890.5	309.84
G61710AG	1869.25	174.57
G30622WV	1517	129.07

GlyTouCan ID	Binding Intensity	Stdev
G87373RB	44394	1046.87
G18059CR	39064.25	2226.27
G48059CD	15086.25	910.07
G94393CX	11751	884.16
G90411BS	10647.75	1126.48
G61710AG	10259.5	399.75
G30622WV	7255	1267.56
G63110FF	6485.25	1143.5
G79420BT	5355.75	733.98
G85278ER	5182.75	121.91

GlyTouCan ID	Binding Intensity	Stdev
G87373RB	129369	8066.65
G18059CR	105579.8	6787.77
G61710AG	49652.5	799.31
G90411BS	38441.5	3528.07
G48059CD	36398.75	318.83
G94393CX	22991	457.47
G63110FF	21722	1472.06
G30622WV	15948.5	1771.01
G96548CQ	15212.5	3049.26
G85278ER	13893.5	810.92

GlyTouCan ID	Binding Intensity	Stdev
G87373RB	98680.5	4556.69
G18059CR	76970.25	5967.5
G90411BS	29474	495.17
G61710AG	25622.25	2799.67
G94393CX	21625.25	2083.47
G48059CD	21541	1297.42
G63110FF	17481.5	2269.48
G30622WV	11806.5	616.85
G96548CQ	10017.25	804.12
G72506RN	8674.5	945.39

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.

MCAW-DB (Glycan Recognition Profile)

1935
2987

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).