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Concanavalin-A

Summary

Lectin Name Aliases

Canavalia Ensiformis Agglutinin
ConA

Monosaccharide Specificities

Organism

Canavalia ensiformis (jack bean)

External Links

UniProt

P02866

LfDB

LfDB0170

UniLectin

P02866

CarboGrove

Annotation

Keyword

3D-structure
Antiviral protein
Calcium
Direct protein sequencing
Glycoprotein
Manganese
Mannose-binding
Metal-binding
Plant defense
Signal

Gene Ontology (GO)

Displaying **all 2** entries
GO Term
defense response
regulation of defense response to virus

Displaying **all 2** entries
GO Term
mannose binding
metal ion binding

Annotation information from UniProt.

Reference

Displaying entries **21 - 30** of 35 in total

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PubMed ID	Title	First Author
8663112	Sequential structural changes upon zinc and calcium binding to metal-free concanavalin A.	Bouckaert J
9045661	Thermodynamics of lectin-carbohydrate interactions. Binding of the core trimannoside of asparagine-linked carbohydrates and deoxy analogs to concanavalin A.	Gupta D
9575151	Diocleinae lectins are a group of proteins with conserved binding sites for the core trimannoside of asparagine-linked oligosaccharides and differential specificities for complex carbohydrates.	Dam TK
9830027	Thermodynamics of binding of the core trimannoside of asparagine-linked carbohydrates and deoxy analogs to Dioclea grandiflora lectin.	Dam TK
9830028	Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates.	Rozwarski DA
9830029	Differential solvation of core trimannoside complexes of the Dioclea grandiflora lectin and concanavalin A detected by primary solvent isotope effects in isothermal titration microcalorimetry.	Dam TK
9949195	Protein glycosylation mutants of procyclic Trypanosoma brucei: defects in the asparagine-glycosylation pathway.	Hwa KY
11504727	Functional equality in the absence of structural similarity: an added dimension to molecular mimicry.	Goel M
11751924	Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.	Zhao R
15632152	Thermodynamic, kinetic, and electron microscopy studies of concanavalin A and Dioclea grandiflora lectin cross-linked with synthetic divalent carbohydrates.	Dam TK

UniLectin

UniProt
P02866

CarboGrove

Lectin Name: Canavalia Ensiformis Agglutinin
Common Name: ConA

Automated Analysis report (Top 10 high affinity glycans)

Array Source

CFG

Protein Source

EY Labs

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G00091RT	1349.14	42.73
G47212KG	1169.44	109.36
G34861UP	1093.21	29.03
G65997KL	884.18	63.37
G00619DD	759.72	75.91
G63337SS	596.92	62.5
G40702WU	579.33	60.32
G80966KZ	553.58	51.76
G22768VO	553.19	34.3
G23046QV	537.28	21.1

GlyTouCan ID	Binding Intensity	Stdev
G47212KG	8673.48	586.43
G00091RT	7143.29	117.84
G80966KZ	6147.92	249.94
G65997KL	6004.18	20.08
G55220VL	5983.17	468.05
G22768VO	5813.81	428.84
G34861UP	5350.19	679.97
G23046QV	5249.23	454.67
G63337SS	4364.06	474.22
G40702WU	3746.42	1996.26

GlyTouCan ID	Binding Intensity	Stdev
G00619DD	14138.04	476.44
G40702WU	12297.31	1411.67
G22768VO	11399.87	413.22
G80966KZ	8982.17	608.92
G47212KG	8166.97	852.21
G00091RT	7542.78	296.35
G65997KL	6303.89	1239.03
G55220VL	5784.36	412.76
G23046QV	5258.45	451
G22768VO	5073.08	413.49

GlyTouCan ID	Binding Intensity	Stdev
G55220VL	50032.28	15865.61
G80966KZ	48820.92	17487.58
G40702WU	41125.42	3952.89
G34861UP	38880.13	3474.49
G22768VO	38005.31	4640.52
G00619DD	37576.2	5132.95
G22768VO	36419.06	2388.17
G65997KL	35116.39	4972.97
G00091RT	34350.2	2244.73
G69411IG	33134.55	1481.94

GlyTouCan ID	Binding Intensity	Stdev
G04791QM	50437.38	16341.13
G90725ZC	48019.51	12978.04
G80966KZ	47253.38	7710.76
G91365ZQ	46131.5	3221.39
G00767OE	43344.42	2804.16
G91257NC	42289.72	7288.57
G54953LX	41914.09	750.5
G39213VZ	41515.33	14898.17
G84467IZ	41415.68	4324.94
G03577YK	41158.45	926

GlyTouCan ID	Binding Intensity	Stdev
G84467IZ	61880.12	3859.38
G31865AG	58407.51	5200.72
G40702WU	55881.75	6663.95
G30694RX	54931.52	8771.66
G84467IZ	52132.48	14617.54
G19687OL	49497.29	5696.16
G96919WB	49090.09	8985.14
G03577YK	48815.2	2284.85
G14047PA	48590.34	9173.26
G18320HP	48324.53	3776.08

CarboGrove View

Array Source

Reichardt

Protein Source

EY Labs

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G38297TU	56115.5	0
G51872EK	50941	0
G20624LQ	48872.5	0
G03652TR	48261.5	0
G70073SG	46079	0
G44747CU	44083.5	0
G88876JQ	34930.75	0
G86386QT	32503.75	0
G93164KQ	29083.25	0
G04445KN	26196.5	0

GlyTouCan ID	Binding Intensity	Stdev
G17336FF	59492	0
G04445KN	55743	0
G86386QT	53887	0
G44747CU	53004.33	0
G70073SG	50134.25	0
G38297TU	49354.5	0
G20624LQ	49106.75	0
G88876JQ	48713	0
G66741YQ	47555	0
G56653RI	46308.25	0

GlyTouCan ID	Binding Intensity	Stdev
G56653RI	58599.75	0
G47498FQ	57922.5	0
G17336FF	56822.5	0
G44747CU	54968	0
G04445KN	53080	0
G66741YQ	51013.25	0
G86386QT	50448.25	0
G88876JQ	49522.25	0
G70073SG	48461.5	0
G20624LQ	46971.75	0

CarboGrove View

Array Source

ASNLinked

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G03652TR	7442	745
G22768VO	4912	172
G78059CC	4260	146
G36191CD	4103	179
G73866ZM	3803	135
G66741YQ	3407	142
G56749GV	2344	203
G84467IZ	2305	134
G61207RZ	2168	126
G80858MF	2163	77

GlyTouCan ID	Binding Intensity	Stdev
G03652TR	25728	2098.86
G22768VO	17219.5	3082.4
G39213VZ	14345.75	4269.84
G80858MF	11903.25	285.4
G78059CC	11274.5	433.64
G66741YQ	11200.75	363.19
G73866ZM	10544.75	279.31
G36191CD	10164	184.49
G84467IZ	7818.25	521.18
G61207RZ	6403.25	1600.54

CarboGrove View

Array Source

ASYMN

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G07483YN	1350.17	103.42
G61751GZ	1301.33	66.31
G89036WC	1195.17	97.03
G69411IG	1149.83	118.13
G64481DJ	1071.67	24.23
G28663KH	780	150.17
G06209KS	703.33	33.93
G14996IQ	487.83	51.91
G66937TJ	372	14.55
G95081VM	360.33	5.13

GlyTouCan ID	Binding Intensity	Stdev
G61751GZ	20785.5	764.62
G07483YN	19341.67	1289.27
G69411IG	18572.5	560.18
G64481DJ	18158.83	1108.58
G89036WC	16264.67	861.33
G28663KH	16106	402.82
G06209KS	12935.67	790.7
G14996IQ	9766.67	777.28
G97720QM	8748	979.92
G88421PE	8326.33	1341.58

GlyTouCan ID	Binding Intensity	Stdev
G61751GZ	51303.67	1259
G07483YN	50407.33	1115.27
G28663KH	49849.33	1228.08
G69411IG	48340.33	2914.36
G64481DJ	46242.5	1768.47
G89036WC	43939.67	596.72
G06209KS	43085.83	1152.38
G14996IQ	42869.83	569.62
G97720QM	40354	1700.18
G88421PE	39312.83	765.28

GlyTouCan ID	Binding Intensity	Stdev
G05368PM	65423	14.95
G07995VK	65198.17	533.1
G80858MF	65135.17	302.5
G90725ZC	64858.33	660.76
G06969ZX	64819.33	556.32
G89993FE	64738.67	582.87
G65597BI	64378.33	618.21
G27919IH	64292	882.07
G63787RZ	64278.5	583.45
G75850OP	64173.67	585.98

CarboGrove View

Array Source

CFG

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G47212KG	34118.96	1537.66
G00619DD	29844.45	2264.28
G80966KZ	28737.54	1581.85
G55220VL	28717.16	1880.27
G65997KL	26066.75	1086.53
G34861UP	25444.25	749.51
G22768VO	24240.06	1684.91
G00091RT	23492.21	891.65
G63337SS	23332.01	1640.48
G23046QV	23237.42	2432.52

GlyTouCan ID	Binding Intensity	Stdev
G22768VO	39464.87	2785.49
G00619DD	39369.1	3299.58
G80966KZ	39082.66	6192.05
G94983ZY	36495.82	2139.16
G55220VL	36471.35	3005.53
G47212KG	36349.66	1268.08
G40702WU	35441.79	3565.95
G63337SS	34751.41	1266.75
G57891XD	34021.08	2391.95
G23046QV	33663.76	1506.48

GlyTouCan ID	Binding Intensity	Stdev
G56749GV	35447.85	2672.58
G55220VL	35154.52	2041.33
G64633BH	33564.17	1807.88
G84467IZ	32517.48	1571.8
G00619DD	32284.77	1206.41
G80966KZ	32225.46	3655.79
G31865AG	31341.34	1303.14
G65997KL	31159.19	1513.78
G62112AO	30973.02	1029.21
G22768VO	30942.63	2613.9

GlyTouCan ID	Binding Intensity	Stdev
G77252PU	54623.8	5433.72
G30694RX	46069.8	1268.99
G80156FT	45896.21	1558.81
G34108KW	45795.01	2135.73
G18320HP	45368.05	3352.92
G17689DH	44978.29	3259.99
G42463OP	44962.81	4295.42
G92140GK	44882.2	942.78
G19026NP	44052.51	1137.82
G73305LV	43399.19	2666.77

CarboGrove View

Array Source

NCFG

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G80966KZ	46036	5236
G69411IG	37305	5518
G55220VL	35680	1969
G34861UP	35237	4405
G23046QV	34177	1453
G65997KL	32025	4557
G94983ZY	27649	2579
G82348BZ	25886	1180
G22768VO	25847	1526
G31865AG	24923	1470

GlyTouCan ID	Binding Intensity	Stdev
G31152NK	49390	619
G80966KZ	45830	3773
G42463OP	43592	2516
G73305LV	41919	1969
G75850OP	41167	2480
G19687OL	41074	3719
G84467IZ	40386	3861
G23046QV	40255	1929
G37796OS	39647	7314
G77252PU	39356	2953

CarboGrove View

Array Source

NGGM

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G82207VX	6843	0
G59513YA	6748	0
G98602UY	3685	0
G70851FQ	858	0
G88876JQ	607	0
G44909WI	379	0
G60956VN	277	0
G78509IY	143	0
G86522OD	54	0
G96428WC	47	0

GlyTouCan ID	Binding Intensity	Stdev
G59513YA	19054	0
G82207VX	11929	0
G98602UY	10192	0
G70851FQ	1703	0
G88876JQ	970	0
G44909WI	906	0
G60956VN	350	0
G78509IY	128	0
G86522OD	96	0
G88356HA	48	0

CarboGrove View

Array Source

NGGM-TM

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G59513YA	2492.5	150.14
G82207VX	1986.75	159.16
G98602UY	1212.75	223.36
G44909WI	260.75	55.33
G60956VN	161.25	10.5
G45827GY	147	32.73
G10422IZ	135	25.83
G88876JQ	112.75	8.42
G04156GK	79	11.69
G48600JD	61	25.59

GlyTouCan ID	Binding Intensity	Stdev
G59513YA	30258.25	813.7
G82207VX	24611	1176.88
G98602UY	15841.25	2741.7
G44909WI	11925.75	1593.79
G88876JQ	4180.75	236.67
G70851FQ	1763.75	121.5
G60956VN	1578.5	79.12
G45827GY	490.75	125.88
G86522OD	135	17.17
G10422IZ	125	85.38

GlyTouCan ID	Binding Intensity	Stdev
G82207VX	59715	1413.64
G98602UY	59609.75	2273.37
G44909WI	58515.75	1545.16
G59513YA	52895.5	1303.59
G88876JQ	43063.25	3155.39
G60956VN	23652	802.92
G70851FQ	20382.75	961.26
G86522OD	11194.75	390.78
G78509IY	4776.25	164.9
G01685IB	251.25	18.23

GlyTouCan ID	Binding Intensity	Stdev
G98602UY	63387	1839.45
G86522OD	62999.75	692.09
G60956VN	62067.75	1583.84
G44909WI	61682.25	1130.44
G88876JQ	59954.5	1231.21
G82207VX	58892.25	386.26
G59513YA	57383.25	1464.32
G70851FQ	57219.75	4327.04
G78509IY	52793.75	1647.75
G01685IB	5372.25	414.45

GlyTouCan ID	Binding Intensity	Stdev
G78509IY	65366	77.32
G44909WI	65309	110.71
G86522OD	65293	129.87
G60956VN	65274	95.03
G98602UY	64800	220.9
G70851FQ	64614.5	600.43
G82207VX	64473	480.91
G59513YA	63857.25	672.43
G88876JQ	63009.75	414.44
G01685IB	15755.25	1080.8

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G73866ZM	49996.67	0
G35722YG	49537.67	0
G58236FD	48462.83	0
G21005TQ	47749.5	0
G12715AH	47650.83	0
G37591JC	45396.17	0
G31865AG	43613.67	0
G98223HN	43204.67	0
G88495BI	42556.5	0
G70851FQ	42490.33	0

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G37591JC	52759.5	0
G25632TA	51889.63	0
G42028VS	50019	0
G01169EW	49758.88	0
G82221BU	49041.88	0
G63565MO	48938.88	0
G52971DE	48386.63	0
G44754DF	48173.75	0
G36859SD	47892.63	0
G58236FD	47786.63	0

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G66741YQ	22423.83	0
G73683LQ	22341.66	0
G03652TR	22206.5	0
G86053IC	22060.16	0
G86053IC	21170.5	0
G38297TU	20968.66	0
G56202TA	20966.33	0
G29024OJ	20879.83	0
G96896RL	20791.5	0
G19747OA	20752.83	0

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G51964GO	25123.25	0
G56202TA	24421.5	0
G19747OA	23542.25	0
G03652TR	23035.5	0
G78800HY	18395.25	0
G49764YU	17306.5	0
G21745UQ	17239.25	0
G03116ET	13205.25	0
G51379UR	11681.75	0
G29313LW	11623	0

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G44747CU	33656.25	0
G20624LQ	32964.25	0
G38297TU	30723.25	0
G93164KQ	30264.75	0
G56202TA	29281.25	0
G66741YQ	28790.25	0
G12715AH	28348.75	0
G73866ZM	27742.5	0
G19532EC	27653.25	0
G74290AC	27566.75	0

CarboGrove View

Array Source

ZBiotech

Protein Source

Vector

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G85856KC	55078.5	0
G94080QH	17815.33	0
G68639CF	14631.92	0
G28052FT	4627.5	0
G44528IE	253.17	0
G59126YU	195.42	0
G15557BG	84.67	0
G01582PV	64.75	0
G13469SG	29.58	0
G86678MP	7	0

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.

MCAW-DB (Glycan Recognition Profile)

5342

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).