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MIRAGE
Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Streptococcus mutans | Unknown | Salivary glycoprotein (gp340) | Glycoproteins | Dental plaque (caries-associated) | Binding | 11007786 | |
| Listeria innocua | Unknown | Mannose 6-phosphate insulin-like growth factor-II receptor (M6P/IGF-IIR) | Glycoproteins | Fetal calf serum | Binding | 16369013 | |
| Rhinovirus | Unknown | ICAM-1 (intercellular adhesion molecule-1) domain1/2 | Glycoproteins | Primary chicken embryo fibroblasts (CEFs) | Binding | 1356290 | |
| Listeria monocytogenes | Unknown | Mannose 6-phosphate insulin-like growth factor-II receptor (M6P/IGF-IIR) | Glycoproteins | Fetal calf serum | Binding | 16369013 | |
| Neisseria meningitidis | PorA | C4b-binding protein (C4bp) | Glycoproteins | Serum | Binding | 15879129 | |
| Pseudomonas aeruginosa | Flagellin | MUC1 mucin | Glycoproteins | Epithelial cells | Binding | 11880301 | |
| Bordetella pertussis | Unknown | Fetuin | Glycoproteins | Bovine | Binding | 14532091 | |
| Bordetella pertussis | Fim2 (H1/H2) | Heparin | Glycosaminoglycans | ECM | Binding | 11348687 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparin | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Bordetella pertussis | FHA (442-863) | Heparin | Glycosaminoglycans | WiDr cells, HeLa cells, Vero cells, Extracellular matrix (ECM) | Binding | 11348687 | |
| Bordetella pertussis | FHA (442-863) | Heparin | Glycosaminoglycans | Respiratory epithelial cells | Binding | 17106803 | |
| Foot-and-mouth disease virus | Natural ligand of integrin [alpha]v[beta]3 | Heparin | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 8764038 | |
| Herpes simplex virus | Unknown | Heparin | Glycosaminoglycans | Human cervical cells | Binding | 9420059 | |
| Borrelia burgdorferi | BBK32 | Heparin | Glycosaminoglycans | Mammalian cell surface | Binding | 16368999 | |
| Shigella dysenteriae | Stx | Platelet-specific GSL (Stx band 0.03) | Glycosphingolipids | Human platelets | Binding | 9712788 | |
| Cryptococcus neoformans | Adhesins | Sucrose | Monosaccharides | Human lung epithelial cell line (A549) | Binding | 9453390 | |
| Cryptococcus neoformans | Adhesins | Inositol | Non-glycosylated Lipids | Human lung epithelial cell line (A549) | Binding | 9453390 | |
| Clostridium botulinum | Botulinum neurotoxin (type D) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Presynaptic neuronal cells | Binding | 18242046 | |
| Pseudomonas aeruginosa | exoenzyme S | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Epithelial cells | Binding | 9224879 | |
| Campylobacter upsaliensis | 5 bacterial surface proteins (50 to 90-kDa) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | HEp-2 cells | Binding | 8926069 | |
| Campylobacter upsaliensis | Unknown | Lyso-PE | Non-glycosylated Lipids | HEp-2 cells | Binding | 8926069 | |
| Clostridium botulinum | BoNT/D (two lysine residues (K1117 and K1135 in Hc/D1)) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Presynaptic neuronal cells | Binding | 18242046 | |
| Helicobacter pylori | SabA (sialic acid-binding adhesin) | Fucosylated Lewis b (Leb) histoblood group antigens | Oligosaccharides | Mucosal surface of the gastric epithelium | Binding | 12640357 | |
| Norovirus | Unknown | Blood group O antigen | Oligosaccharides | Human saliva | Binding | 16707048 | |
| Helicobacter pylori | BabA (blood group antigen binding adhesin) | Fucosylated Lewis b (Leb) histoblood group antigens | Oligosaccharides | Human gastric epithelium | Binding | 9430586 |
