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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding ▲ | PubMed ID |
|---|---|---|---|---|---|---|---|
| Actinomyces naeslundii | Type-2 fimbrial lectins (130-kDa glycoprotein) | Galactose | Monosaccharides | Polymorphonuclear leukocytes (PMNs) | Gal | Binding | 7790078 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Entamoeba histolytica | Gal/GalNAc Lectins (260-kDa) | N-Acetylgalactosamine | Monosaccharides | c-Met on hepatocytes | GalNAc | Binding | 9878032 |
| Entamoeba histolytica | Gal/GalNAc Lectins (260-kDa) | Galactose | Monosaccharides | c-Met on hepatocytes | Gal | Binding | 9878032 |
| Hantaan virus | DBA (Dolichos biflorus agglutinin) | N-Acetylgalactosamine | Monosaccharides | Vero E6/P388D1 cells | GalNAc | Binding | 10542025 |
| Actinomyces naeslundii | Adhesins | N-Acetylgalactosamine | Monosaccharides | HL-60 promyelocytic leukemia cell line, Leukosialin (CD43) | GalNAc | Binding | 11035744 |
| Actinomyces naeslundii | Adhesins | Galactose | Monosaccharides | HL-60 promyelocytic leukemia cell line, Leukosialin (CD43) | Gal | Binding | 11035744 |
| Escherichia coli | F17 | N-Acetylglucosamine | Monosaccharides | Urine (microvilli of the intestinal epithelium of ruminants) | GlcNAc | Binding | 16564136 |
| Cryptococcus neoformans | Adhesins | N-Acetylglucosamine | Monosaccharides | Human lung epithelial cell line (A549) | GlcNAc | Binding | 9453390 |
| Cryptococcus neoformans | Adhesins | N-Acetylgalactosamine | Monosaccharides | Human lung epithelial cell line (A549) | GalNAc | Binding | 9453390 |
| Streptococcus pneumoniae | Adhesins | N-Acetylgalactosamine | Monosaccharides | Type-II lung cells, Vascular endothelial cells | GalNAc | Binding | 7752878 |
| Streptococcus pneumoniae | Adhesins | D-Mannose | Monosaccharides | Type-II lung cells, Vascular endothelial cells | Man | Binding | 7752878 |
| Streptococcus pneumoniae | Adhesins | D-Galactose | Monosaccharides | Vascular endothelial cells (only) | Gal | Binding | 7752878 |
| Escherichia coli | Type 1-pili | D-Mannose | Monosaccharides | Bladder epithelium | Man | Binding | 12010488 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Clostridium botulinum | HA | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | HA | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Rabies virus | Unknown | N-Acetylglucosamine | Monosaccharides | Chicken embryo related cells | GlcNAc | Binding | 3583664 |
| Rabies virus | Unknown | Galactose | Monosaccharides | Chicken embryo related cells | Gal | Binding | 3583664 |
| Rabies virus | Unknown | Mannose | Monosaccharides | Chicken embryo related cells | Man | Binding | 3583664 |
| Escherichia coli | FimCH-chaperone-adhesin complex | D-Mannose | Monosaccharides | Bladder epithelium | Man | Binding | 12010488 |
| Klebsiella pneumoniae | Unknown | Mannose | Monosaccharides | Respiratory tract | Man | Binding | 16564136 |
| Entamoeba histolytica | Raft-like plasma membrane domains | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
