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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name ▼ | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Clostridium tetani | Tetanus neurotoxin | Polysialogangliosides and other acidic lipids | Glycolipids | Presynaptic membrane of neuromuscular junction | Binding | 7527117 | |
| Clostridium tetani | TeNT | Polysialogangliosides and other acidic lipids | Glycolipids | Presynaptic membrane of neuromuscular junction | Binding | 7527117 | |
| Plasmodium falciparum | Unknown | Polylactosamine of band 3 | Polysaccharides | Binding | 8574698 | ||
| Poliovirus | Unknown | Poliovirus receptors (PVRs) | Glycoproteins | Binding | 12663789 | ||
| Shigella dysenteriae | Stx | Platelet-specific GSL (Stx band 0.03) | Glycosphingolipids | Human platelets | Binding | 9712788 | |
| Escherichia coli | CsgA (curli) | Plasminogen | Glycoproteins | Binding | 9973330 | ||
| Salmonella enteritidis | AgfA (curli) | Plasminogen | Glycoproteins | Binding | 9973330 | ||
| Helicobacter pylori | Unknown | Phospholipids | Non-glycosylated Lipids | Binding | 16088272 | ||
| Campylobacter upsaliensis | Unknown | Phosphatidylserine (PS) | Non-glycosylated Lipids | Binding | 8926069 | ||
| Clostridium botulinum | Botulinum neurotoxin (type D) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Presynaptic neuronal cells | Binding | 18242046 | |
| Pseudomonas aeruginosa | exoenzyme S | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Epithelial cells | Binding | 9224879 | |
| Campylobacter upsaliensis | 5 bacterial surface proteins (50 to 90-kDa) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | HEp-2 cells | Binding | 8926069 | |
| Clostridium botulinum | BoNT/D (two lysine residues (K1117 and K1135 in Hc/D1)) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Presynaptic neuronal cells | Binding | 18242046 | |
| Helicobacter pylori | Unknown | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Binding | 16088272 | ||
| Pseudomonas aeruginosa | PA-IL (51-kDa) | Phenyl-β-thiogalactoside | Saccharides | Binding | 15049333 | ||
| Human immunodeficiency virus | Unknown | Pentosan polysulfate (PP) | Polysaccharides | Human T cells | Binding | 9420059 | |
| Chlamydia trachomatis | Unknown | Pentosan polysulfate (PP) | Polysaccharides | HeLa cells | Binding | 9420059 | |
| Herpes simplex virus | Unknown | Pentosan polysulfate (PP) | Polysaccharides | Human cervical cells | Binding | 9420059 | |
| Neisseria gonorrhoeae | Unknown | Pentosan polysulfate (PP) | Polysaccharides | Human epithelial cells | Binding | 9420059 | |
| Haemophilus influenzae | Unknown | Pentasaccharide | Oligosaccharides | Respiratory tract | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Streptococcus pneumoniae | Unknown | Pentasaccharide | Oligosaccharides | Respiratory tract | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Neisseria meningitidis | Unknown | Pentasaccharide | Oligosaccharides | Respiratory tract | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Streptococcus gordonii | Adhesins | PMN (polymorphonuclear leukocytes) surface glycoproteins in the presence of sialic acid | Glycoproteins | Human peripheral blood buffy coat cells | Binding | 11035744 | |
| Actinomyces naeslundii | Adhesins | PMN (polymorphonuclear leukocytes) surface glycoproteins | Glycoproteins | Human peripheral blood buffy coat cells | Binding | 11035744 | |
| Helicobacter pylori | Adhesins | PGCs (polyglycosyl ceramides) | Glycosphingolipids | Human leukocytes, Human neutrophils | Binding | 10569742 |
