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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding ▲ | PubMed ID |
|---|---|---|---|---|---|---|---|
| Polyoma virus | Capsid protein VP1 | Sialylated oligosaccharides | Oligosaccharides | Cell surface | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 8805524 |
| Helicobacter pylori | Unknown | unnamed ligand | Oligosaccharides | Stomach | NeuAc(a2-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Polyoma virus | Unknown | Sialylated oligosaccharides | Oligosaccharides | Erythrocytes | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 6316632 |
| Escherichia coli | K99 | unnamed ligand | Oligosaccharides | Intestinal cells | NeuAc(a2-3)Gal(b1-4)Glc | Binding | 16564136 |
| Influenza virus | Residues 226 (glutamine) and 228 (glycine) | Sialic acid linked to α2,3Galβ1,3GalNAc | Oligosaccharides | Avian/equine isolates | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 7975212 |
| Polyoma virus | Unknown | unnamed ligand | Oligosaccharides | Murine small plaque | NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc | Binding | 8574698 |
| Reovirus | Unknown | Sialic acid (α2,6) | Saccharides | Most organs including the central nervous system/heart/liver | NeuAc(a2-6) | Binding | 18216114 |
| Bordetella pertussis | Adhesins | terminal Gal(3SO4) β1- residues | Sulfoglycosphingolipids | Human lung, Human trachea | Gal(3SO4)(b | Binding | 1918002 |
| Bordetella pertussis | FHA (filamentous hemagglutinin) | Sulfatide (CSE) | Sulfoglycosphingolipids | Cell surface | HSO3(-3)Gal(b1-1)Cer | Binding | 10341176 |
| Mycoplasma pneumoniae | Adhesins | Sulfatide (CSE) | Sulfoglycosphingolipids | Erythrocytes | HSO3(-3)Gal(b1-1)Cer | Binding | 2470754 |
| Helicobacter pylori | Adhesins | Sulfatide (CSE) | Sulfoglycosphingolipids | Human gastric mucosa | HSO3(-3)Gal(b1-1)Cer | Binding | 2037054 |
| Mycoplasma pneumoniae | Unknown | Sulfo-lactosylceramide (SM3) | Sulfoglycosphingolipids | Human colon adenocarcinoma cells (WiDr ) | HSO3(-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2470753 |
| Human immunodeficiency virus | gp120 | Sulfatide (CSE) | Sulfoglycosphingolipids | Human U373-MG glioma and SK-N-MC neuroblastoma cells, Human colon epithelial HT29 cells | HSO3(-3)Gal(b1-1)Cer | Binding | 15973004 |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | Sulfatide (CSE) | Sulfoglycosphingolipids | Human meconium | HSO3(-3)Gal(b1-1)Cer | Binding | 9228091 |
| Human immunodeficiency virus | Envelope glycoprotein gp120 | Galactosyl sulfatide | Sulfoglycosphingolipids | Neural receptor | HSO3(-3)Gal(b1-1)Cer | Binding | 1871126 |
| Lactobacillus casei | Unknown | Sulfatide (CSE) | Sulfoglycosphingolipids | Intestinal tract | HSO3(-3)Gal(b1-1)Cer | Binding | 8912650 |
| Clostridium botulinum | Botulinum neurotoxin (type C) | GT1b | Trisialoglycosphingolipids | Presynaptic neuronal cells | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18242046 |
| Clostridium tetani | Tetanus toxin | GT1b | Trisialoglycosphingolipids | Brain membrane | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 6257717 |
| Clostridium botulinum | BoNT/C (located within amino acid residues 1122-1290) | GT1b | Trisialoglycosphingolipids | Presynaptic neuronal cells | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18242046 |
| Influenza virus | Hemagglutinin (HA) | GT1b | Trisialoglycosphingolipids | Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 11030743 |
| Clostridium tetani | Unknown | GT1b | Trisialoglycosphingolipids | Brain membrane | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 6257717 |
| Actinomyces naeslundii | Type-2 fimbrial lectins | GD1a | Disialoglycosphingolipids | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 3804448 | |
| Actinomyces naeslundii | Type-2 fimbrial lectins | GD1b | Disialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 3804448 | |
| Escherichia coli | K99 | GD1a(NeuGc) | Disialoglycosphingolipids | NeuGc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuGc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 7849044 | |
| Vibrio cholerae | Cholera toxin | GD1b | Disialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 8574698 |
