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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name ▼ | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Entamoeba histolytica | Gal/GalNAc Lectins (260-kDa) | N-Acetylgalactosamine | Monosaccharides | c-Met on hepatocytes | GalNAc | Binding | 9878032 |
| Hantaan virus | DBA (Dolichos biflorus agglutinin) | N-Acetylgalactosamine | Monosaccharides | Vero E6/P388D1 cells | GalNAc | Binding | 10542025 |
| Actinomyces naeslundii | Adhesins | N-Acetylgalactosamine | Monosaccharides | HL-60 promyelocytic leukemia cell line, Leukosialin (CD43) | GalNAc | Binding | 11035744 |
| Cryptococcus neoformans | Adhesins | N-Acetylgalactosamine | Monosaccharides | Human lung epithelial cell line (A549) | GalNAc | Binding | 9453390 |
| Streptococcus pneumoniae | Adhesins | N-Acetylgalactosamine | Monosaccharides | Type-II lung cells, Vascular endothelial cells | GalNAc | Binding | 7752878 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | HA | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Entamoeba histolytica | Raft-like plasma membrane domains | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Pseudomonas aeruginosa | PA-IL (51-kDa) | N-Acetylgalactosamine | Monosaccharides | GalNAc | Binding | 15049333 | |
| Entamoeba histolytica | Membrane-associated lectins (heavy(170-kDa)/light(35-or31-kDa) subunits) | N-Acetylgalactosamine | Monosaccharides | GalNAc | Binding | 10225860 | |
| Pseudomonas aeruginosa | PA-IL | N-Acetylgalactosamine | Monosaccharides | GalNAc | Binding | 10967261 | |
| Escherichia coli | Unknown | N-Acetylgalactosamine | Monosaccharides | GalNAc | Binding | 2885220 | |
| Entamoeba histolytica | 52-kDa recombinant fusion proteins | N-Acetylgalactosamine | Monosaccharides | GalNAc | Binding | 8574698 | |
| Escherichia coli | K99 | Mucin | Glycoproteins | Intestinal cells | Binding | 7849044 | |
| Bordetella pertussis | Iron-induced surface-exposed proteins | Mucin | Glycoproteins | Respiratory epithelial cells (A549) | Binding | 17727651 | |
| Campylobacter upsaliensis | Unknown | Mucin | Glycoproteins | Human small intestine | Binding | 8926069 | |
| Helicobacter pylori | Unknown | Mucin | Glycoproteins | Binding | 16088272 | ||
| Fusobacterium nucleatum | Lectin-like proteins (adhesin) | Mr 89,000 PRG (Proline-Rich Glycoprotein) | Glycoproteins | Binding | 1894623 | ||
| Fusobacterium nucleatum | Lectin-like proteins (adhesin) | Mr 36,900 PRG (Proline-Rich Glycoprotein) | Glycoproteins | Binding | 1894623 | ||
| Helicobacter pylori | Unknown | Monohexyl ceramides (MHCer) | Glycolipids | Binding | 16088272 | ||
| Helicobacter pylori | Unknown | Mono-de-N-acetylated S-3-PG (paragloboside) | Glycosphingolipids | Binding | 15659615 | ||
| Helicobacter pylori | Unknown | Mono-N-propionylated S-3-PG (paragloboside) | Glycosphingolipids | Binding | 15659615 | ||
| Influenza virus | SNA lectins | Minor NeuAcα6-containing molecules | Glycoconjugates | Human leukocytes | Binding | 11030743 | |
| Pseudomonas aeruginosa | PA-IL | Methyl-β-Gal | Monosaccharides | Binding | 10967261 |
