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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name ▼ | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Bordetella pertussis | Pertactin | Integrins | Glycoproteins | Binding | 12640357 | ||
| Cryptococcus neoformans | Adhesins | Inositol | Non-glycosylated Lipids | Human lung epithelial cell line (A549) | Binding | 9453390 | |
| Streptococcus pneumoniae | PspC (Lary family) (alias: SpsA/CbpA/PbcA/Hic) | IgA | Glycoproteins | Binding | 12640357 | ||
| Streptococcus pneumoniae | SpsA | IgA | Glycoproteins | Binding | 10341176 | ||
| Rhinovirus | Unknown | ICAM-1 (intercellular adhesion molecule-1) domain1/2 | Glycoproteins | Primary chicken embryo fibroblasts (CEFs) | Binding | 1356290 | |
| Influenza virus | Unknown | I-active ganglioside | Sialoglycosphingolipids | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 7870741 | |
| Influenza virus | Hemagglutinin (HA) | I-active ganglioside | Sialoglycosphingolipids | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 12628483 | |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | I-active ganglioside | Sialoglycosphingolipids | Human placenta | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9228091 |
| Influenza virus | Unknown | I-active ganglioside | Sialoglycosphingolipids | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7870741 | |
| Rotavirus | Unknown | I-active Sialyl lactoisooctaosylceramide | Sialoglycosphingolipids | Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 11160731 | |
| Mycoplasma pneumoniae | Unknown | I-active Sialyl lactoisooctaosylceramide | Sialoglycosphingolipids | Human colon adenocarcinoma cells (WiDr ) | Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2470753 |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | I-active Sialyl lactoisooctaosylceramide | Sialoglycosphingolipids | Bovine erythrocytes | Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9228091 |
| Mycoplasma pneumoniae | Unknown | I-active Lactoisooctaosylceramide | Oligoglycosylceramides | Human colon adenocarcinoma cells (WiDr ) | Gal(b1-4)GlcNAc(b1-6)[Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2470753 |
| Mycoplasma pneumoniae | Unknown | I-active Gal2-lactoisooctaosylceramide | Oligoglycosylceramides | Human colon adenocarcinoma cells (WiDr ) | Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[Gal(a1-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2470753 |
| Escherichia coli | CsgA (curli) | Human contact phase proteins | Glycoproteins | Binding | 9973330 | ||
| Salmonella enteritidis | AgfA (curli) | Human contact phase proteins | Glycoproteins | Binding | 9973330 | ||
| Influenza virus | Hemagglutinin | Human and avian receptors containing sialylated glycoconjugates | Glycoconjugates | Airways | Binding | 18809496 | |
| Influenza virus | Hemagglutinin H1(1934) | Human and avian receptors containing sialylated glycoconjugates | Glycoconjugates | Airways | Binding | 18809496 | |
| Paramyxovirus | Hemagglutinin H1(1934) | Human and avian receptors containing sialylated glycoconjugates | Glycoconjugates | Airways | Binding | 18809496 | |
| Streptococcus gordonii | Ca2+-independent lectins | Hs antigen | Glycoproteins | NeuAc(a2-3)Gal(b1-4)Glc-HSA | Binding | 9393794 | |
| Streptococcus gordonii | Ca2+-independent lectins | Hs antigen | Glycoproteins | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc-HSA | Binding | 9393794 | |
| Trypanosoma cruzi | CBPs (carbohydrate-binding proteins) | High mannose glycans containig the Manα1-2Manα1-6Manα1-6 structure | Saccharides | Man(a1-2)Man(a1-6)Man(a1-6) | Binding | 11555616 | |
| Borrelia burgdorferi | Unknown | Heparin (completely desulfated, N-acetylated) | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Borrelia burgdorferi | Unknown | Heparin (N-desulfated, N-acetylated) | Glycosaminoglycans | Vero cells | Binding | 9826395 | |
| Bordetella pertussis | Fim2 (H1/H2) | Heparin | Glycosaminoglycans | ECM | Binding | 11348687 |
