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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID ▲ |
|---|---|---|---|---|---|---|---|
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Entamoeba histolytica | Raft-like plasma membrane domains | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Entamoeba histolytica | Raft-like plasma membrane domains | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Entamoeba histolytica | Raft-like plasma membrane domains | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Sporothrix schenckii | Yeast cells and hyphae | Fibronectin | Glycoproteins | Extracellular matrix (ECM) | Binding | 15351036 | |
| Sporothrix schenckii | Yeast cells and hyphae | Laminin | Glycoproteins | Extracellular matrix (ECM) | Binding | 15351036 | |
| Streptococcus pneumoniae | CTB-PsaA pentamers | GM1 | Monosialoglycosphingolipids | Serum, Saliva, Nasal/bronchial wash samples | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 15358234 |
| Helicobacter pylori | Unknown | Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) | Monosialoglycosphingolipids | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 15659615 | |
| Helicobacter pylori | Unknown | Sialyl Lewis x (SLex) antigen (d18:1,18:0) | Oligosaccharides | NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b | Binding | 15659615 | |
| Helicobacter pylori | Unknown | Mono-N-propionylated S-3-PG (paragloboside) | Glycosphingolipids | Binding | 15659615 | ||
| Helicobacter pylori | Unknown | Mono-de-N-acetylated S-3-PG (paragloboside) | Glycosphingolipids | Binding | 15659615 | ||
| Adenovirus | Fibre proteins | HSA glycoconjugates | Glycoproteins | Human corneal epithelial(HEC) cells | Binding | 15678425 | |
| Helicobacter pylori | SabA (sialic acid-binding adhesin) | Sialic acid | Monosaccharides | Human neutrophils | Binding | 15689619 | |
| Parvovirus | Unknown | O-linked alpha 2,3 neuraminic acid on glycophorin A (GPA) | Glycoproteins | Human erythrocytes | Binding | 15750863 | |
| Clostridium botulinum | Progenitor toxin (type A) | Lactose | Disaccharides | Intestine-407 cells | Gal(b1-4)Glc | Binding | 15850798 |
| Clostridium botulinum | Progenitor toxin (type A) | N-acetyllactosamine (LacNAc) | Disaccharides | Intestine-407 cells | Gal(b1-4)GlcNAc | Binding | 15850798 |
| Clostridium botulinum | Unknown | Lactose | Disaccharides | Intestine-407 cells | Gal(b1-4)Glc | Binding | 15850798 |
| Clostridium botulinum | Unknown | N-acetyllactosamine (LacNAc) | Disaccharides | Intestine-407 cells | Gal(b1-4)GlcNAc | Binding | 15850798 |
| Neisseria meningitidis | PorA | C4b-binding protein (C4bp) | Glycoproteins | Serum | Binding | 15879129 | |
| Human immunodeficiency virus | gp120 | Sulfatide (CSE) | Sulfoglycosphingolipids | Human U373-MG glioma and SK-N-MC neuroblastoma cells, Human colon epithelial HT29 cells | HSO3(-3)Gal(b1-1)Cer | Binding | 15973004 |
| Mycoplasma pneumoniae | Unknown | Glycoproteins with terminal NeuAcα3Galβ4GlcNAc-sequences | Glycoproteins | NeuAc(a2-3)Gal(b1-4)GlcNAc | Binding | 15973004 | |
| Vibrio cholerae | Cholera toxin | GM1 | Monosialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 15973004 | |
| Clostridium tetani | Tetanus neurotoxin | GM2(NeuAc) | Monosialoglycosphingolipids | GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 15973004 | |
| Clostridium botulinum | Neurotoxin (type A/B) | GM2(NeuAc) | Monosialoglycosphingolipids | GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 15973004 |
