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Effects of PIP2 hydrolysis

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-114508

PubChem

R-HSA-114508

Description

Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P24723	Protein kinase C eta type	PKCL PRKCH PRKCL	view
P52824	Diacylglycerol kinase theta	DAGK4 DGKQ	view
Q04759	Protein kinase C theta type	PRKCQ PRKCT	view
Q13507	Short transient receptor potential channel 3	TRP3 TRPC3	view
Q13574	Diacylglycerol kinase zeta	DAGK6 DGKZ	view
Q14571	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2	ITPR2	view
Q14573	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3	ITPR3	view
Q14643	Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1	INSP3R1 ITPR1	view
Q16760	Diacylglycerol kinase delta	DGKD KIAA0145	view
Q5KSL6	Diacylglycerol kinase kappa	DGKK	view

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