Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
EPAS1SUCCACO22OGHIF2AO2HP-HIF3AHIF3A2OG2xHP-HIF1AHIF1ACO2O2SUCCAPHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3hydroxyPro-HIF-alphaUBE2D1,2,3UBE2D1,2,3:Ubiquitinub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1)UbVBC complex (with or without LIMD1)HIF1A2xHP-HIF1AEPAS12xHP-EPAS1HP-HIF3AHIF3AVHL:EloB,C:CUL2:RBX1hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1hydroxyPro-HIF-alphaUBE2D1,2,3UBE2D1,2,3:Ubiquitin
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 3 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_004978 Q9GZT9 Egl nine homolog 1 view
GL_005016 Q96KS0 Prolyl hydroxylase EGLN2 view
GL_005250 Q9H6Z9 Prolyl hydroxylase EGLN3 view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025